ID E3BH03_9VIBR Unreviewed; 384 AA.
AC E3BH03;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:EFP97640.1};
GN ORFNames=VIBC2010_00245 {ECO:0000313|EMBL:EFP97640.1};
OS Vibrio caribbeanicus ATCC BAA-2122.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=796620 {ECO:0000313|EMBL:EFP97640.1, ECO:0000313|Proteomes:UP000002943};
RN [1] {ECO:0000313|EMBL:EFP97640.1, ECO:0000313|Proteomes:UP000002943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2122 {ECO:0000313|EMBL:EFP97640.1,
RC ECO:0000313|Proteomes:UP000002943};
RX PubMed=21930677; DOI=10.1099/ijs.0.032375-0;
RA Hoffmann M., Monday S.R., Allard M.W., Strain E.A., Whittaker P., Naum M.,
RA McCarthy P.J., Lopez J.V., Fischer M., Brown E.W.;
RT "Vibrio caribbeanicus sp. nov., isolated from the marine sponge
RT Scleritoderma cyanea.";
RL Int. J. Syst. Evol. Microbiol. 62:1736-1743(2012).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFP97640.1}.
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DR EMBL; AEIU01000052; EFP97640.1; -; Genomic_DNA.
DR RefSeq; WP_009600249.1; NZ_AEIU01000052.1.
DR AlphaFoldDB; E3BH03; -.
DR STRING; 796620.VIBC2010_00245; -.
DR eggNOG; COG0845; Bacteria.
DR OrthoDB; 9800613at2; -.
DR Proteomes; UP000002943; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000002943};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 56..283
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 284..350
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
SQ SEQUENCE 384 AA; 42322 MW; 63759C829CA32CCD CRC64;
MYKAGIIFLA ILSLVGCDSD KAQTPKNSPI QVDTIRVTQV EQALSVDLPG RTKAFREAEV
RPQVNGIITK RIFTEGSFVK QGESLYQVDP APYQAKLVSA KAEVEANKAN LYAAETRLKR
TQRLVSRGAL SQQELDDTLA TYKVSRAALQ VSEAALNQAE INLEYTKVKA PISGLIGRSL
VTEGTLVTSG QEQMLARIQQ LDPINIDLSR SSAEIFKIKN AYRKGEFREE SEPTITLLMG
TQQYPARAKI KFTEVNVNSA TDSVTIRAEF PNKKAILLPG MYVRARLNIG TDPNAILIPQ
KAVTRNSKGQ AIVMLVDPEG TVKQKVIETA EVIGDKWRIT SGLEEGDRVV ISNLQRIHSG
DHVEAIEQNR PKIKEVTPRR GASD
//
