ID E3BPY5_9VIBR Unreviewed; 303 AA.
AC E3BPY5;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=VIBC2010_02546 {ECO:0000313|EMBL:EFP94910.1};
OS Vibrio caribbeanicus ATCC BAA-2122.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=796620 {ECO:0000313|EMBL:EFP94910.1, ECO:0000313|Proteomes:UP000002943};
RN [1] {ECO:0000313|EMBL:EFP94910.1, ECO:0000313|Proteomes:UP000002943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2122 {ECO:0000313|EMBL:EFP94910.1,
RC ECO:0000313|Proteomes:UP000002943};
RX PubMed=21930677; DOI=10.1099/ijs.0.032375-0;
RA Hoffmann M., Monday S.R., Allard M.W., Strain E.A., Whittaker P., Naum M.,
RA McCarthy P.J., Lopez J.V., Fischer M., Brown E.W.;
RT "Vibrio caribbeanicus sp. nov., isolated from the marine sponge
RT Scleritoderma cyanea.";
RL Int. J. Syst. Evol. Microbiol. 62:1736-1743(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- SIMILARITY: Belongs to the bacterial reverse transcriptase family.
CC {ECO:0000256|ARBA:ARBA00034120}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFP94910.1}.
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DR EMBL; AEIU01000111; EFP94910.1; -; Genomic_DNA.
DR RefSeq; WP_009603247.1; NZ_AEIU01000111.1.
DR AlphaFoldDB; E3BPY5; -.
DR STRING; 796620.VIBC2010_02546; -.
DR eggNOG; COG3344; Bacteria.
DR OrthoDB; 7055795at2; -.
DR Proteomes; UP000002943; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd03487; RT_Bac_retron_II; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000123; Reverse_transcriptase_msDNA.
DR InterPro; IPR000477; RT_dom.
DR NCBIfam; NF038233; retron_St85_RT; 1.
DR PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR34047:SF7; RNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00866; RNADNAPOLMS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EFP94910.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002943};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:EFP94910.1};
KW Transferase {ECO:0000313|EMBL:EFP94910.1}.
FT DOMAIN 14..235
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 303 AA; 35101 MW; B0DB6CF3E92872A5 CRC64;
MLLELISKNT LIEKDQVLDI ANKASTLYAR FTIPKKDGSE RLIYQPSMAI RALQKVVYDG
VLDKLPVHDA CYAYRKGRGL KEHANIHRNS KYLLRIDLKD FFESITRSDI EKYCNEYVSK
VFPIFNEGDF NLMIDIICRK NTITIGSVTS PSLSNSICYN LDEKISRLSD SYGVKYTRYA
DDMFFSTTNK NILKIIQKEV SSIIKKLDYP KLTINNKKTR HSSKKNRMSV TGVVITVDKK
LSIGRDKKRF IRGQVYNWKN LSIEEKSYLS GYLSFVKSVE PSYINRLCDK YSSHVIQEIL
RFS
//
