ID E3CBP9_STRPA Unreviewed; 647 AA.
AC E3CBP9;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:EFQ55849.1};
GN ORFNames=HMPREF9626_0092 {ECO:0000313|EMBL:EFQ55849.1};
OS Streptococcus parasanguinis F0405.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=905067 {ECO:0000313|EMBL:EFQ55849.1, ECO:0000313|Proteomes:UP000003812};
RN [1] {ECO:0000313|EMBL:EFQ55849.1, ECO:0000313|Proteomes:UP000003812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0405 {ECO:0000313|EMBL:EFQ55849.1,
RC ECO:0000313|Proteomes:UP000003812};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFQ55849.1}.
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DR EMBL; AEKM01000003; EFQ55849.1; -; Genomic_DNA.
DR RefSeq; WP_003002098.1; NZ_AEKM01000003.1.
DR AlphaFoldDB; E3CBP9; -.
DR Proteomes; UP000003812; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 449..591
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 647 AA; 72939 MW; 66DBB4D5799FB599 CRC64;
MSQIIELPEV LANQIAAGEV IERPASVVKE LVENSIDAGA SQIIVEIEEA GLKSIRITDN
GEGIAQDEVA LALRRHATSK IKSQADLFRI RTLGFRGEAM PSIASVSILT LLTAQEGAAH
GTKLVAKGGE IEEVEPATSP VGTKITVEDL FFNTPARLKY LKSQQAELSH IVDILNRLSL
AHPEIAFTLI NDGKEMTKTA GTGNLRQAIA GVYGLASAKK MVAIENRDLD FEVTGFVSLP
ELTRANRNYI SLFINGRYIK NFLLNRAILD GYGSKLMVGR FPLAIINIQI DPYLADVNVH
PTKQEVRISK ERELMALISQ AIANALKEQD LIPDALENLA KSTIRRTEKL VQTTLPLKEN
RLYYDRESQD FKLRPEVADP QRPLADETAT EARIQENPVE KPTSAIKFAE RKTAVYDELD
HPELDLASLD KAYDKLDGEE HSTFPELEYF GQMHGTYLFA QGNGGLYIID QHAAQERVKY
EEYRESIGDV DGSQQQLLVP YIFEFPADDL IRLQQRKHLL EEVGVYLEEY GANQLILREH
PIWMKEEEIE SGIYEMCDML LLTKEVSIKK YRAELAIMMS CKRSIKANHT LDDYSARDLI
YQLSQCDNPY NCPHGRPVLV NFTKSDMEKM FRRIQENHTS LRELGKY
//
