ID E3DRU7_HALPG Unreviewed; 698 AA.
AC E3DRU7;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Hprae_2039 {ECO:0000313|EMBL:ADO78161.1};
OS Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=572479 {ECO:0000313|EMBL:ADO78161.1, ECO:0000313|Proteomes:UP000006866};
RN [1] {ECO:0000313|Proteomes:UP000006866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33744 / DSM 2228 / GSL
RC {ECO:0000313|Proteomes:UP000006866};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Ovchinnikova G., Chertkov O., Detter J.C., Han C., Larimer F., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Tindall B., Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Halanaerobium praevalens DSM 2228.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADO78161.1, ECO:0000313|Proteomes:UP000006866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33744 / DSM 2228 / GSL
RC {ECO:0000313|Proteomes:UP000006866};
RX PubMed=21886858;
RA Ivanova N., Sikorski J., Chertkov O., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA Huntemann M., Liolios K., Pagani I., Mavromatis K., Ovchinikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M.,
RA Kannan K.P., Rohde M., Tindall B.J., Goker M., Detter J.C., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P., Lapidus A.;
RT "Complete genome sequence of the extremely halophilic Halanaerobium
RT praevalens type strain (GSL).";
RL Stand. Genomic Sci. 4:312-321(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP002175; ADO78161.1; -; Genomic_DNA.
DR RefSeq; WP_014554177.1; NC_017455.1.
DR AlphaFoldDB; E3DRU7; -.
DR STRING; 572479.Hprae_2039; -.
DR REBASE; 28402; M.HprORF2039P.
DR KEGG; hpk:Hprae_2039; -.
DR PATRIC; fig|572479.3.peg.2077; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_012122_0_0_9; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000006866; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ADO78161.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006866};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..134
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 147..458
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 698 AA; 80963 MW; 9D0E38D0161B72F2 CRC64;
MNNFGEKVNF IWNIANLLRG PYKPEKYGDI ILPLSVLRRF DCILEPTKDK VLEKAKQVEI
PELLNAAAGL KFHNKSKYDF EKLLDDPDNI AENLRAYIRG FSANIREIME NFDFDKEITK
LNSNNLLFLV VKEFNKLDLH PEKVSNQEMG YIFEELIRRF SENAEAGDHY TPREVIELMV
NIIFSGEEDV VTNPANISTI GDFACGTGGM LSVAENYIHK MNKEAEVALY GQEINDQSYA
ICKADMLIKD EGENADNIAL GNSLTNDLHK GLRVRYGLMN PPFGVSWSKD SKEVKKEHKN
QGFDGRFGAG TPRTSDGSLL FLQHMLSKMK TDKKGSRMAI IFNGSPLFTG DANSGESEIR
RWIIENDLLE GIIALPEELF YNTGIATYIW VLSNRKNDDL AKGPIRKDKI QLVDATSFSE
PMRKSLGKKR NKITKPQINR ITEIYGAFQD NEYSQIFDKE EFGYLKVRIE RPLKLNFKIT
EDRIENIYAE NTFSKLFDEE KYKKLKKLSE APEFKSKDKN KLEKLEAGKK LQDKILNRLR
ANIEQDKVWK NRKEFKEVLK EILGDLDLKR SLMKAVRNGL AKRDETADYC KKRGKIESDT
DLRDYERILF SHKVEGYKQD YSDFVEKEKD NIQTYFEEEV KPHVPEAWVD YSYTRVGYEI
PFTRYFYEFE ELEPSHKIKE DIEKLEAEIN EIMQKVLG
//
