ID E3GXW1_METFV Unreviewed; 406 AA.
AC E3GXW1;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Mur ligase middle domain protein {ECO:0000313|EMBL:ADP77143.1};
GN OrderedLocusNames=Mfer_0340 {ECO:0000313|EMBL:ADP77143.1};
OS Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanothermaceae; Methanothermus.
OX NCBI_TaxID=523846 {ECO:0000313|EMBL:ADP77143.1, ECO:0000313|Proteomes:UP000002315};
RN [1] {ECO:0000313|EMBL:ADP77143.1, ECO:0000313|Proteomes:UP000002315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S
RC {ECO:0000313|Proteomes:UP000002315};
RX PubMed=21304736;
RA Anderson I., Djao O.D., Misra M., Chertkov O., Nolan M., Lucas S.,
RA Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C.,
RA Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA Mikhailova N., Pati A., Brambilla E., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Sikorski J., Spring S., Rohde M.,
RA Eichinger K., Huber H., Wirth R., Goker M., Detter J.C., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Methanothermus fervidus type strain (V24S).";
RL Stand. Genomic Sci. 3:315-324(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002278; ADP77143.1; -; Genomic_DNA.
DR RefSeq; WP_013413421.1; NC_014658.1.
DR AlphaFoldDB; E3GXW1; -.
DR STRING; 523846.Mfer_0340; -.
DR GeneID; 9962055; -.
DR KEGG; mfv:Mfer_0340; -.
DR HOGENOM; CLU_629483_0_0_2; -.
DR OrthoDB; 76119at2157; -.
DR Proteomes; UP000002315; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008764; F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:InterPro.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR005762; MurD.
DR PANTHER; PTHR43692; UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE; 1.
DR PANTHER; PTHR43692:SF1; UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF51984; MurCD N-terminal domain; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ADP77143.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002315}.
FT DOMAIN 99..220
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
SQ SEQUENCE 406 AA; 46344 MW; 23A2E25D1EA952A1 CRC64;
MDTKKVAVLG LGVEGKNAIK SLKKRGYRIY ASDKNRIDFK DEEVEVDLGK HDINKILSCD
FVVISPSMWN TKLASLIKKK KKVICDVFNK HKSIYTIGVT GTNGKTTTSL MIYEILKNSK
KNVLIGGNAG GGFEGYTELI LEANEGNYEY MVIEICDMTL DFVDDCFDLD MVVVTNIGED
HLNYHKTLEN FRRKLKKFLK NKIAILNSKD PNLVKLAKEL DNYIFYDEYD VPLFGRFNKL
NAGAAAAAAK FLGIDPKIIS HTLKNFKLPK GRLKHYNINN KHIIIGKTDN KTALEAVLNE
MKFDAMFIGT PRRNEYWRFK ILDVAYKSSP KLIVLFPGLE DTVDMAKKRL EKLGFKNVVT
VKTIDEIVKM FEFVLEKYEK IFIGGNGQKK INKIQDILEA KFVQYQ
//
