ID E3LZV0_CAERE Unreviewed; 638 AA.
AC E3LZV0;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=CRE-OTPL-7 protein {ECO:0000313|EMBL:EFO87834.1};
GN Name=Cre-otpl-7 {ECO:0000313|EMBL:EFO87834.1};
GN ORFNames=CRE_05541 {ECO:0000313|EMBL:EFO87834.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; DS268420; EFO87834.1; -; Genomic_DNA.
DR RefSeq; XP_003110541.1; XM_003110493.1.
DR AlphaFoldDB; E3LZV0; -.
DR STRING; 31234.E3LZV0; -.
DR EnsemblMetazoa; CRE05541.1; CRE05541.1; WBGene00053102.
DR eggNOG; KOG4740; Eukaryota.
DR HOGENOM; CLU_011508_3_1_1; -.
DR InParanoid; E3LZV0; -.
DR OMA; AKDCIHI; -.
DR OrthoDB; 2877304at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:InterPro.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522:SF29; OTOPETRIN-LIKE; 1.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR Pfam; PF03189; Otopetrin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 267..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71719 MW; CD8996BCA5E23E5E CRC64;
MEPLREKESI VSVASTSCAP PGHLSLPDTL ISPSPSEDPL LEHPQWIRNP KATRFLVGLL
TSMYVLLLTI VSCLIALSSA WNSPDLWLAE TVGIQIYFQI FSLLMYGIAT LFFMYTYFVV
IYPKPINTLI LFLNRKTSFI PRPDRWLIPP ALHNGEGAGT LYLRLGALLF GTLGSVLWGC
EIYLCFAGEC VHRLVVSKHI AAIIFTFLQM HFIVCNSKIT FHRSNHLASF GMMHCVAVNI
WTWFSMCLVK AQVKRLKKQK KEMEYHKNST DSYSSSSSSS SSSSEEEDEL ESSTVLEGLV
EAVVEKMKPM MSSYSSSTSS YPTYSYNSTS NHTLLRMQSM ARLGDFSSFL LTCLVEYSLI
GAAVCFIIWK YMGATSIEEN VDKKKKKLRM DCTSTTVGLF AGIFFMTAAF VTIGIYTMLY
NKKNAAGADL VIGIVNLVLF CVALVAVIFG SWRMRVLQYR LHAHGEVIDE ILLIIGLVGE
LVYCSIGFDM IINGRRTGKN APNLAIAVFT FRIVQVIIQA MYILIASRLR CLSTANTQYQ
PGKQTLTFLV IINISLFVYH AFEGMKSTYG FPSIMESKYF ELLNISSPLV VFYRFHSSAC
LAEIWKHTYS TKHNHHHHHN VLSPISSPMS DNSHHNHV
//
