ID E3M6S5_CAERE Unreviewed; 509 AA.
AC E3M6S5;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN ORFNames=CRE_10008 {ECO:0000313|EMBL:EFO93059.1}, GCK72_014716
GN {ECO:0000313|EMBL:KAF1758258.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|EMBL:EFO93059.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|EMBL:EFO93059.1};
RG The Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF1758258.1, ECO:0000313|Proteomes:UP000483820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX506 {ECO:0000313|EMBL:KAF1758258.1,
RC ECO:0000313|Proteomes:UP000483820};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KAF1758258.1};
RA Teterina A.A., Willis J.H., Phillips P.C.;
RT "Chromosome-level assembly of the Caenorhabditis remanei genome.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC {ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
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DR EMBL; DS268426; EFO93059.1; -; Genomic_DNA.
DR EMBL; WUAV01000004; KAF1758258.1; -; Genomic_DNA.
DR RefSeq; XP_003108259.1; XM_003108211.1.
DR AlphaFoldDB; E3M6S5; -.
DR STRING; 31234.E3M6S5; -.
DR EnsemblMetazoa; CRE10008.1; CRE10008.1; WBGene00059463.
DR GeneID; 9828866; -.
DR KEGG; crq:GCK72_014716; -.
DR CTD; 9828866; -.
DR eggNOG; KOG3830; Eukaryota.
DR HOGENOM; CLU_014030_1_0_1; -.
DR InParanoid; E3M6S5; -.
DR OMA; DIMYRMN; -.
DR OrthoDB; 8983at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR Proteomes; UP000483820; Chromosome iv.
DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU368069};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Signal {ECO:0000256|RuleBase:RU368069}.
FT REGION 32..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 57559 MW; C8833EEF53528CB8 CRC64;
MATPVKFDSE CHLHAVMCFL AGQTGEKIVS IYPHRKPPPK APPKESTPAS STPGVSMKPV
LTSVKDPSVG FGLVETEFDM SLGMLAQAVK TQEIGCNDGF DMKINNQRFV GYPKTWKARG
GNTNYQILIV FALKQGCDQH TAAAYQTLSN KIAVSFVMLQ NYFGFLERED KWADMADSAD
DPLREFSKTS FMVQTLIDMY DEVRKRGNIH KYQINFVELG FCDEAHALSR LNVVPKGRQD
IDEIVRKMKP YHGILLLEDV WPTPDANPIV AKLLSHCSPD RSILDMSTAS GIPIFEVFMI
IRHLLQWTRA ILIYPLCNTN IYTSATSPQP LDKMAEKFAA QFGTTIHLAA GLSHFNPPKT
LDTFIRPNLP LHEQGVRAKL VVALLRHQML MQLHQFYYIL KPYSNAVLPD PIEQCPEEFI
KLIFDSQLPN DDVKRVVADI CAEMLSHTAY GAVKRKLTLF MKCVPMMNGN HHLEDIKYKN
NLDRAEIESI FKSFELVIAT FRRPDFVAE
//
