ID E3M749_CAERE Unreviewed; 1406 AA.
AC E3M749;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=CRE_12654 {ECO:0000313|EMBL:EFO93786.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR EMBL; DS268427; EFO93786.1; -; Genomic_DNA.
DR RefSeq; XP_003107887.1; XM_003107839.1.
DR STRING; 31234.E3M749; -.
DR EnsemblMetazoa; CRE12654.1; CRE12654.1; WBGene00072492.
DR eggNOG; KOG0261; Eukaryota.
DR HOGENOM; CLU_000487_3_0_1; -.
DR InParanoid; E3M749; -.
DR OMA; AVCPPYN; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02736; RNAP_III_Rpc1_C; 1.
DR CDD; cd02583; RNAP_III_RPC1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR035698; RNAP_III_Rpc1_C.
DR InterPro; IPR035697; RNAP_III_RPC1_N.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 249..554
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1406 AA; 156666 MW; 6A947F916310D266 CRC64;
MGKEQFREAD KALKVVGVKF APGDCEFMRQ TAHVPIFNNK LYEDVGGKLQ PANYGPLDPR
MGVSTKTGTC ATCGLGLTDC VGHFGYFDLD VPVFHIGFFK LTIQLLQCIC KQRNFQNCSS
ILLNPEQHRV FSRQVMNPNI DYLHRKALHK RIVAACKKSS TCTQCGLKNG TVKKAVGTVL
KIAFASPVPA DELGKYATMF NANQEVGDHV KKMKFTLLNP LFVQKLFANV KQADIPVLMV
RSGEEKHPND LLLTRMPVPP VCIRPSVVSE VKSGTTEDDV TMKLMEIMLT NDVLKKHKRD
GAPSKTLFET WEHLQIQCAL YINSEMSGLP PDMQPKKAMR SFTQRLKGKQ GRFRGNLCGK
RVDFSGRTVI SPDPNLRIDQ VGVPIHVAMT LTFPEIVNAS NIEKMRQLVI NGSDIHPGAN
YLVDKKTGNK KLLKYGKRDE LAKLLRLGDT VERHLDDNDV VLFNRQPSLH KISIMSHRAK
VMPGRTFRFN ECACTPYNAD FDGDEMNLHL PQTYEAKAEA SELMNVKNNL ITPRSGEPLV
AAIQDFITGG YLLTHKDTFL PRAEVYRFAA ALIDASAKKQ TKIRIPPPAI RKPVELWTGK
QLIELIIRPD KGSQISLNLT AKNKSYSGNL ELCSKDSYVI IRNSVLLAGV LDKSLLGSSS
KVNIFYMLMR DYGEDAAVDA MWRLARMAPV FLSNRGFSIG IGDVRPSERL LQEKGQLVDT
GYEQCAQYIR ELEEGKLKAQ PGCTEEETLE AIILRELSTI RDHAGQVCLR NLSKYNAPLT
MAVCGSKGSF INISQMIACV GQQAISGHRP PDGFEERSLP HFERKKKTPE AKGFVANSFY
SGLTPTEFFF HTMGGREGLV DTAVKTAETG YMQRRLVKCL EDLCASYDGT VRSSVGDVIE
FVFGEDGLDP AMMEAKDGSV VDFTHVLEHA KNIQTKKETP IPADKLEDVL KNEVQKQFKG
KYPHFAEQLK DFLQTEIRKS KKWQNGKTHC SQHETAEENI REKCAKCKNM AEYKSLLLTN
SCLTKAQLHS FIQLCYYKVA RAITEPGTAV GAIAATSIGE PSTQMTLKTF HFAGVASMNI
TQGVPRIKEI INAVKTISTP IITAALLDPY DESLARRVKA RIEKTTLGEI CDYIEEVYLP
DDYFLLVKLN SKRIRLLQLE VSLESIAFAI STSKVCPMMR GCKIVAHGKT MMAIRPPSTS
KLSKTMTMQM LKYSLGNVVI KGISSVNRCV IHADEKKGDF YSLLVEGTDF RSVLSSVGVD
PRKTNFNNAL VVAEVLGIEA ARTCIINEII ATMDAHGIGL DRRHVMLLAD VMTYRGEVLG
ITRNGLVKMK DSVLLLASFE KTMDHLFEAA FFSQRDVIHG VSECIIMGTP MTVGTGTFKL
MQKHEKKAIL KQNSPIFQRP ETTITL
//
