ID E3MCY5_CAERE Unreviewed; 4379 AA.
AC E3MCY5;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=CRE-CDH-4 protein {ECO:0000313|EMBL:EFO98508.1};
GN Name=Cre-cdh-4 {ECO:0000313|EMBL:EFO98508.1};
GN ORFNames=CRE_20360 {ECO:0000313|EMBL:EFO98508.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DS268435; EFO98508.1; -; Genomic_DNA.
DR RefSeq; XP_003105982.1; XM_003105934.1.
DR STRING; 31234.E3MCY5; -.
DR EnsemblMetazoa; CRE20360.1; CRE20360.1; WBGene00061766.
DR eggNOG; KOG1219; Eukaryota.
DR HOGENOM; CLU_000042_2_0_1; -.
DR InParanoid; E3MCY5; -.
DR OMA; YSSLYYE; -.
DR OrthoDB; 2961370at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:EnsemblMetazoa.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0097402; P:neuroblast migration; IEA:EnsemblMetazoa.
DR CDD; cd11304; Cadherin_repeat; 27.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 30.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 15.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 28.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 29.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 27.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..4379
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003176572"
FT TRANSMEM 4120..4141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..154
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 157..276
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 385..492
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 609..720
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 744..849
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 850..957
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 958..1074
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1070..1179
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1198..1285
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1288..1386
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1387..1490
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1499..1596
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1694..1807
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1906..2006
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2104..2209
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2210..2313
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2314..2425
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2457..2533
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2534..2642
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2643..2746
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2754..2847
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2947..3046
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3047..3148
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3149..3251
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3252..3371
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3372..3473
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3474..3599
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3753..3791
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3804..3972
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3976..4013
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4015..4051
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4210..4260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4315..4370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4228..4258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3762..3779
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3781..3790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3945..3972
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 4003..4012
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4041..4050
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4379 AA; 487199 MW; 4272969270E61D79 CRC64;
MKKHRVFYLF LLIFCKSVNL VTTSSSSTEQ IFEFTAPLYN LSVEENSIGS KYARSENSTK
IGVPLPEKDA NCKFRVAEIV GEKSSLFKAH SRQVGDFVFL RIRYKGDNPL NRELKDFYDI
LVKATCKRRD LSNLETTARI HLRVIDRNDA SPVFLIDEQG YEAEIDDDTE PFSTVLRVEA
SDADIGINSA IYFSLVNRSH DFIVEPVTGW IRTLRHVKPG KYSLKVKSED RASRLYYFDE
NEVQPSWTAD VLITVRETKL KQTKITVDRR KISPNELKTR QLAAIITLKD APKDALVGLK
GNEKEHLFEI EMEEKTNLVI QEVRWMLYAK NGTKVPKNTN VTFTVGEDYV RKSGFSISKK
PVIPVNETIT IQIDHLSEHS IEFNSKEKLT IRTDEMAPIG RVLSRFNVIV ENPDDVSLIR
FSIFNSNPSF NTTLPFSIGS KTGILRVSSK LVLTERVYNF KVAANLNGIE GKTDETDVSI
EVLDSNDHSP VWSAKWMRQV PIPIGKVGEV LLKVDVTDQD EGDNGRVVYK INSELPLEIN
ANTGEIKLIE FPKKGSNWIA TVWAVDLGLP LSRMSALNLM FYKNGTKIPP KPKPIIIQES
ENKHSPIFSS FPEVVEVTED APFGTIVAKL QASDEDSGYN GLIRYVIHEV PESYLEILSV
DEQSGEITVA SDLTLLMKEK KEIVEIQVKV SAIDAGNPVK STTKTMKLRI KDVNNHSPQF
DEASRDTKNE FVGGQKREKN SNLFQPSYYV TISENEKPGK DIFKVTANDF DGGNNGKIKF
SLGNNGAESS FISIDSKTGI IKLLKSLDRE YQDVHNFAII ASDGGFPTRV SVTNLTLTVD
DINDNAPRCV SQRSKARIPE DLPHGAFVSC LAAFDEDIGQ NSKLKFSLNS EKVPFRIDHH
SGCLFIHAPE SPLDYQKTPN FNLSIEVADH GDPMLSTTCH LYVELVDVAY NHLAIEFDDV
AKEASVYENS EIGTEVIMIE AREMGDEQKL KAENLEYRII GGDGWSYFSI DRKGTVRTTR
ILDRESKSAY WITVEARDSK TDLLKDSRRK AVLHVFIRIL DRNDHRPVAK MPMYIASVAE
NSPANVVIVK VEATDADDVD NDAAAPLTFK IERGDPQSFF RIDLTSGYIT TSGIRRLDRE
KQSEHELWVS ICDGGEPQLC SNVIVIVNVL DENDNAPTFT QAIHHYNVRS KFVGKLCRIF
AVDSDEGENA RLSYNITEGD PRFSIDENGN IITSEAIHGD ESYALTVQAT DHGTPSQQFA
ATRVVLTANG AGQKAKKTKN SPPVIAGKKS DYVIPISDAD QVGLTVGKLE ASDADGDDLW
WSISSGDSDS VFDVRQDTGQ LLLAKKVELL KRGELRLNIS VTDGQDWDHT TVIIQVSRQI
SQRPKFSASH YQTEVSERVA VGTQIYTLKA SGETLGTKPL VYNLFSVDDI SMEDKIRVEP
SSGNVIVMEP LDYEAARRIR AVVQVQQANM KSFANFAVNI NDENDNSPYF VDHTAWAFVD
ENDSVDDVLA TVTAFDKDQG NNGIISYSIV SGNEESLFKI DSQSGEVRLA RPLDPELQHV
VSILRIRASD SAANSLKDEM NLHIQSSNMA PENAKFDRKV YQTTLHDSTR PGTPILVLSV
LHHGSVSYKL EPNCSFFEVH TLSGAVHLAI WLTKNNNLKS IECTAIVENS EGQQDTAKIV
AKIIRTNQHS PVFREQIYRG TIRENMEPGS SVLSARQLPL VVSAIDEDSG SNGLVGYRML
SAKDDEMFTI DQYSGAIRTK KSFDFEQVKE FSFYVQAFDM GQPPRRSLMP SLVIVSVIDE
NDESPLFPSP SIDVAMLLPT ATGVFVGGQT AKDVDSIGTL RYFIKEKSSP FSVCSKTGNV
YVKDAKTLSD EKKPFNVEIF VTDGKQSASY VMKVSHASEN SKFKFTRQEY HVSVVENTTV
TPGTVILSVA TVGDKLSHYS IVNPHESFFI HHGTGVISST GVVVDREVSP VIRLVVEAKT
HEKNPTIART IVVIDVQNTN DELPTFIGTP YDVSIGTTEI GNAILEPKVI DRDEGDQVVI
SSDDMPEFFK LVGGKVVLAK KLPPIEDKDL EFNFKLIASD NSSVHRVEEL VKIKVVDRAR
PVFSQSIYTA VISKESTKTT TVLVKVMAKS SLQAKSKGLI GYRIVDEKNY FKIDFVTGEI
RLKSLKALEV AEYVFEVEAK EVIRPKMTAR VQVKIIVKSQ FSSMQPPVFE EEKYSVSTPE
SASIGQRILT VKAKSPIEND IVEYKLSGGN DSGFKAFDIH PETGDVTISK SLNYENIQKY
ELKVTATSSV KQVSSEAELI VLIEDVNDEI PVFIKSEVDA QVSDSAISGQ FITIMSATDM
DTTSSLDDSN QKLLYKIVDG DETLFNISPQ TGEVSLARQI EQEDLINEET KKVLNVSVTD
GMFTAYARLM VEILRSGAMQ PAPRFEQSHY VANALENTIV NKSALLTVAV KGGIPPLRYS
LGPAASSNSS SNKDSWPVAI DKKTGRIHVS RVLNYHNDKR YQIPLVVEDA TRRRAFSTLT
LSVIDINDKP PFFVLPFYST SIPESAKEGD TILMVSATDE DENDTVRLKI TIEYSLLDGS
ESQFFSVHPR QGTITVAKKL EHKAGVTLSL TIKATDSANP PHHATTTVEI NIASESVKVP
RFSNSHYLFF VPEDADIGNV IGRVQQMETE IDEVRFTIVS GADEPDTQLP FSVERSTGKI
IVRSGLDRER RKQWKMTIRA DAAGGVHAIT TVTVDVGDIN DNAPAFHGDY EKLTISEDAA
VGTSVTIFSA MDRDDSPSGR IHFSLVQKDP HFEMNENSGW LTVSSQLDRE TTDKYQLIAR
ATDEGGFNTD LPFTIIVSDV NDSPPQFERD VFNVDLQLPS TTPILHFDIK DNDLSPNNQS
LLFISQGNEE GIYWIDSENN LLLKRPEMIE HKKNYSLKIT AFDGVFETSS LVNVHLKTIE
DSSVQCPEAN KTVIIPENSK KGTVVLGESS LLGPNTTFKL IGDGIENVFV MNYRNGIVKV
KDSGQVDYEK NQEFEFYRSM IQGNDELCKE RITVLIENIN DNPPKIIEKQ LRVSIEENLP
TSEDSRQYLT RVVAEDADFD IIKFRLLNEF KGIFGIDEES GVVTAVKTLD SESVGLFNLT
VVASDGKFED QATIIVTVID QNDNAPTFEK STYSMKVMES ESIGYELARL QAFGGDTNET
IVYSLKSSKH NQFVRLDLTT GVLTLAKPLD FETLSVLKLT VIAKDSGIPP LESEAQVEIS
VMDENDNPPK FEKDKYIGKV KENTKIGEKV LSVKAIDADS EHFGAVSYEL EMISEGTAEV
RNSDSTPTHT LTIPFTINAQ GDILINQSID YEKVKKYNLK VIAKDGGRPP LLSETLLEIE
IEDENDHPPM FDDCNMTAVV QEGEPIGHRL LKFLISDLDG PSNGAPFTVD IQGDGAKAFK
VNDKLELLTA KKLEHRKKDK YLLTVIAKDV KGKSTDCPLT VYIRQASRHA PTMKPMRIQV
NTLQNELPEG VIGRLKAYDE DEEDQNGLLR FGIVEGSIQS PRAQIQESRP IHAFRVDPTT
GEIWSDHSIS QGLHTFNVTV TDGKFTTVSY VEVQVNSIDN DVIDHAVSIR VRSMTVDEFM
RNHIKEFRRI ISHHLNLDDE NSIQLVSVQS VPSIETSRNR RSRRSNSDDV EVLMTAQRGH
GRGYLKPDHV YSRLKNDFQT LNDQSQRMRY QLITEMCTTG VCIRGECREV IELIEDNWTK
VSTDEFSFVS PFHSRSAQCL CPDGFGGKRC EVETNQCSKS PCENWQLCIP SVFNSTFECV
CPLGMEGEKC SIPSCKNDGK CLEEAELSVG GDGYFEMSLS NEIESRMELE IELKTTTHNG
VIMWSRGIHD YHLLRLVNGS VEYHWDAGTG TGIVASKTQI VDGQWHRITI SRRQRRTRMT
IDDDGLQEAF SPVGSTVVNL YRFSQKLVLG AKVDKGDVTE GVSACFRAIS VDGIKLSKTR
QGMKLFGVQP GCSALTSSPC NDLPCQHGGT CASHGKSQFV CQCPSRYSGN TCEIDLEPCA
SSPCPTGIQC IPFYNDYLCK CPNGFTGKHC EARGFEDHET SSCSKNVCGS SGQCISIPRH
NLESSDFICN CTGGVLQSTP CTEKSEIFTN ILEYLLKAEI VAIILGVLFL LLICCLAFIT
WKCCKKSNDP KYGAHCDVPH MRNTRVLVPV VPPPLPPRGF RNETSNFIGL SSSATTSTRP
MVEVKPYSSD IRYSRSPSAC GSSKGTRKDP LPSDKFRRTD EVSNRIRGSD RRDPRGDVLT
SLRTSPDDWM GIDDRMDSVL KYSRAAAGAV VVGDTELMPV VNDDDYMTMK PRKDKTFDRE
EDHKPPAIPA HATPLESVLK FSSSSSGEEA PRNALYDDPI SLNSQSFDDI DEEVNIHIS
//
