ID E3MD27_CAERE Unreviewed; 965 AA.
AC E3MD27;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=CRE-GLR-1 protein {ECO:0000313|EMBL:EFO98496.1};
GN Name=Cre-glr-1 {ECO:0000313|EMBL:EFO98496.1};
GN ORFNames=CRE_20273 {ECO:0000313|EMBL:EFO98496.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; DS268435; EFO98496.1; -; Genomic_DNA.
DR RefSeq; XP_003105970.1; XM_003105922.1.
DR AlphaFoldDB; E3MD27; -.
DR STRING; 31234.E3MD27; -.
DR EnsemblMetazoa; CRE20273.1; CRE20273.1; WBGene00061805.
DR eggNOG; KOG1054; Eukaryota.
DR HOGENOM; CLU_007257_1_2_1; -.
DR InParanoid; E3MD27; -.
DR OMA; RRSQNLM; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:EnsemblMetazoa.
DR GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR GO; GO:0008328; C:ionotropic glutamate receptor complex; IEA:EnsemblMetazoa.
DR GO; GO:0032589; C:neuron projection membrane; IEA:EnsemblMetazoa.
DR GO; GO:0043025; C:neuronal cell body; IEA:EnsemblMetazoa.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0014069; C:postsynaptic density; IEA:EnsemblMetazoa.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0019899; F:enzyme binding; IEA:EnsemblMetazoa.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0008306; P:associative learning; IEA:EnsemblMetazoa.
DR GO; GO:0007631; P:feeding behavior; IEA:EnsemblMetazoa.
DR GO; GO:0043056; P:forward locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0046959; P:habituation; IEA:EnsemblMetazoa.
DR GO; GO:0006972; P:hyperosmotic response; IEA:EnsemblMetazoa.
DR GO; GO:1905852; P:positive regulation of backward locomotion; IEA:EnsemblMetazoa.
DR GO; GO:1905850; P:positive regulation of forward locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0010035; P:response to inorganic substance; IEA:EnsemblMetazoa.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:EnsemblMetazoa.
DR GO; GO:0050913; P:sensory perception of bitter taste; IEA:EnsemblMetazoa.
DR GO; GO:0007614; P:short-term memory; IEA:EnsemblMetazoa.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:EnsemblMetazoa.
DR GO; GO:0001966; P:thigmotaxis; IEA:EnsemblMetazoa.
DR CDD; cd06380; PBP1_iGluR_AMPA; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF544; GLUTAMATE RECEPTOR 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..965
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003176856"
FT TRANSMEM 597..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..837
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 472..541
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 965 AA; 108501 MW; 02AC1CBE53B43190 CRC64;
MVSSSRKSWR NMLTVLFSLL NITRVEPYPS HIIIKSFGNN EEVSRVALKA MEYTSDHINS
RDDVPFKLAF DHRVVEEGAA VSWNMVNAVC DELKEGAMTL LSSVDGKGIE GIRGVSDALE
MPLISLTAPT NDEQQQFGNL FEVSVRPPIS ELLADFIVHK GWSEVLVMID PLHASLHLPS
LWRHLRTRTN TSVKASMFDL PADETQFETY LMQFNMMRNN ETNRILIDCA SPKRLKRLLI
NIRSAQFNQA NYHYVLANYD FLPYDQEMFQ NGNINISGFN IINKDGREYW SLKKHLKTSS
SLGGGDDVSV EAAVGHDAML VTWHGFAKCL QANDSLFHGT FRHRRFFNRG FPGIYCDPLS
DRSHPNRPFS SFEHGKTIGV AFRNVRIMQI GAKEGTLTGN IEFDRFGNRK NFDVSIVDLV
SNTKATFNSK EILAWRQGVG FFSNRTVAQH SRKSQSDHKD NQVIVLTNLV APFVMIKREC
VEMANLTECQ GNNKFEGFCI DLLKLLADKI EGFNYIIKLG TKAGSKQPDG SWDGMIGELL
NGNAHAVVAS LTINQERERV VDFSKPFMTT GISIMIKKPD KQEFSVFSFM QPLSTEIWMY
IIFAYIGVSV VIFLVSRFSP YEWRVEETSR GGFTISNDFS VYNCLWFTLA AFMQQGTDIL
PRSISGRIAS SAWWFFTMII VSSYTANLAA FLTLEKMQAP IESVEDLAKQ TKIKYGIQGG
GSTASFFKYS SVQIYQRMWR YMESQVPPVF VASYAEGIER VRSHKGRYAF LLEATANEYE
NTRKPCDTMK VGANLNSIGY GIATPFGSDW KDHINLAILA LQERGELKKL ENKWWYDRGQ
CDAGITVDGS SASLNLSKVA GIFYILMGGM VISMLAALGE FLYRSRIEAR KSNSNSMVAN
FAKNLKSALS SQLRLSIEGG AVAQPGSQSH NAIRRQQVAA FLPANEKEAF NNVDRPPSTL
YNTAV
//
