ID E3MHB0_CAERE Unreviewed; 1068 AA.
AC E3MHB0;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
DE AltName: Full=Glucosidase II subunit alpha {ECO:0000256|ARBA:ARBA00042895};
GN ORFNames=CRE_22873 {ECO:0000313|EMBL:EFP01993.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; N-glycan metabolism.
CC {ECO:0000256|ARBA:ARBA00004833}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268445; EFP01993.1; -; Genomic_DNA.
DR RefSeq; XP_003104392.1; XM_003104344.1.
DR AlphaFoldDB; E3MHB0; -.
DR STRING; 31234.E3MHB0; -.
DR EnsemblMetazoa; CRE22873.1; CRE22873.1; WBGene00062885.
DR eggNOG; KOG1066; Eukaryota.
DR eggNOG; KOG2747; Eukaryota.
DR HOGENOM; CLU_288083_0_0_1; -.
DR InParanoid; E3MHB0; -.
DR OrthoDB; 2883913at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06603; GH31_GANC_GANAB_alpha; 1.
DR Gene3D; 3.40.630.30; -; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR033403; DUF5110.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF54; BCDNA.GH04962; 1.
DR Pfam; PF17137; DUF5110; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR Pfam; PF01853; MOZ_SAS; 2.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Glycosidase {ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|RuleBase:RU361185};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1068
FT /note="histone acetyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003174907"
FT TRANSMEM 1034..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 605..882
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT ACT_SITE 760
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 1068 AA; 122528 MW; 17FC6E4FEBA7D9DD CRC64;
MTAGSSWIPL LLLFAAPLAN SDKVFQRQNA KLTGTTPLPP LFSIGYHQCR WNYNDEQDVT
AVNKGFDDHD MPMDVFWLDI EHTDGKKYFT WDKHKFPTPA DMVSKVAEKG RKMVTIVDPH
IKKDDGYYVY KDAKDKGLFV KRTDGSDFEG HCWPGASEYL DFWHPDTRSY WKDQFSFDRY
SGSSSNLHIW NDMNEPPVFS GPEITMDKES IHYGGIEHRE VHNMYGMMYT SATFDGLMAR
TDGKERPFIL SRAGFIGTQR TAAIWTGDNT ADWGHLEIAA PMTLSLSIAG VPFVGADVGG
FFGNPDEQLL SRWYQTGAFQ PFFRAHAHID TRRREPWLFS EQTQGIIREA LRTRYALLPY
WYTLFQQHSQ NGVPPMRPLF YEFESDDSVL EEQKQWMVGS GIMARPVVEK DTFNVQVKLP
RGEKKVEIWR KMLKNTERWF EWISGAEVHG ESIYVDAPIT FTPVYQRGGI IIPTWQRIRR
SATLMKDDPL TLYVALDSNG NSNGEIYLDD GATHDYQSGQ FVKTSFNYKT ESSREAVLEG
EHVDGKYAAK NWVERVVVRG VESSPKMIEV PSNNRKKFQE SQVTVQGECE FSKSEIADIF
KKGDQQARLP ERIQIGTVIM KTWYGSPFPA EFINVRQLYI CEFCFFYARS DLIMQNHAKR
CRLRAPPGVE IYRKDDVSVF EVDGRSQKSY CQTPCLISRM FLESKTVFYD TEPFFFYVAT
KNDAHGCHFT GYFSKEKYEP DVIDLRYALS RREGWNGGPE QPLSDLGKKA YGGYWKNTSA
VSLVKMKDRI EFGGRGISIE DIAHDTGINS HDVISVVCSL GWAKIMTGIS LCKPQKWNQH
IIKIVTALLV IVKTVASSHH SENQNKRKEQ RKSVLVINVT KPMKIGQTIH STSRFRSRSG
FFRRSFDAVS RPLVAIAETF LKESILTKLN TLLCSALSQY GTVIEDIFPF QADCIYAFSW
LLCVTTGVSM YIDYQREKLK TPPVEEYAMN FSYIVSHEAQ NTVFVSVLIW IPTIPNSMSS
CLNWLRHLSE LFEIMVSFFS VSMKIMSVIF YCISFPLVLE YATDYVIF
//
