ID E3MLE8_CAERE Unreviewed; 740 AA.
AC E3MLE8;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=CRE_25677 {ECO:0000313|EMBL:EFP04411.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR EMBL; DS268454; EFP04411.1; -; Genomic_DNA.
DR RefSeq; XP_003103082.1; XM_003103034.1.
DR AlphaFoldDB; E3MLE8; -.
DR STRING; 31234.E3MLE8; -.
DR EnsemblMetazoa; CRE25677.1; CRE25677.1; WBGene00071193.
DR eggNOG; KOG0751; Eukaryota.
DR HOGENOM; CLU_014931_3_0_1; -.
DR InParanoid; E3MLE8; -.
DR OMA; GPDAIPF; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF9; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 159..194
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 230..265
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 400..492
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 499..584
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 592..680
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 740 AA; 82622 MW; CE3EA9EB3903E2A9 CRC64;
MSQHQNDQKT MSFDHLLTST RRRELLQNLG VGNGSDSFSL SPFRTAKCNV ETATSQRCRF
LVKNQFYTNN FFFKIKIIPA IQRANPDILR PIFDRFASKE VKGKKLMTPE DFIRGYLGLY
TEENYNKETI RLLASAADTT KDGDISFEEF CAFEALLCSP DALYLTAFEL FDRNASDTIS
CDEFEAVIRH TQPLVDQDFD FNSDFIKRYF GADKQRNVNY HSFCQLLHDF YEEQGIQAFK
KYDKNGNGTI SSVDFQQIMT TVKGHLLTDF VRNNLIAVSG GGASGHKVTF PYYAAFNSLL
AKMELIKRVY VSNARGNLDI EMTKEEFLHA IQSYTQVTPY EVEILFHLSE LNHPGRKTLC
LKDIQAIDPE RLKRVSQMDR LINIKAVHHK DERGFGTALL ESGYRFLLGS IAGACGATAV
YPIDLVKTRM QNQRTSGSFV GEVMYKNSLD CFKKVVKFEG LLGLYRGLLP QIVGVAPEKA
IKLTMNDFMR DKFTQDGKIP LYGEIIAGGT GGMCQVVFTN PLEIVKIRLQ TAGEVQQAGK
KIGVMSVLKE LGFLGLYKGS RACFLRDIPF SAIYFPAYAH AKLATADEDG MNSPGSLFCS
AFIAGVPAAG LVTPADVIKT RLQVAARAGQ TTYNGVIDCA RKLLKEEGPM SLWKGTAARV
CRSSPQFAVT LLTYEVLQRL FYVDFAGSRP TGSELATTKT IQDESSTNPD HVGGYKLAAA
TFSGIEHKFG LFLPRFETTK
//
