ID E3MM93_CAERE Unreviewed; 366 AA.
AC E3MM93;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=CRE_29935 {ECO:0000313|EMBL:EFP04829.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
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DR EMBL; DS268456; EFP04829.1; -; Genomic_DNA.
DR RefSeq; XP_003102790.1; XM_003102742.1.
DR AlphaFoldDB; E3MM93; -.
DR STRING; 31234.E3MM93; -.
DR EnsemblMetazoa; CRE29935.1; CRE29935.1; WBGene00084139.
DR eggNOG; KOG0939; Eukaryota.
DR HOGENOM; CLU_002173_9_1_1; -.
DR InParanoid; E3MM93; -.
DR OMA; RTTYQPN; -.
DR OrthoDB; 5396290at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 30..366
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 333
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 366 AA; 42645 MW; 174ECA97130FBFA6 CRC64;
MPRYRRNDVS VQVSRNRVFS DSFRELFRLR PSEWKNRFYI IFQGEEGQDA GGLLREWFSV
ITREIFNPNY ALFITAPGDM VTYMINKASY INPEHLDYFK FVGRLIAKSV FEHKYLDCYF
TRAFYKHILN LPVRYQDLES EDPAFFKSLD FLLQNPIDDL GLDLTFSTEV EEFGVRSVRD
LKPNGRKIDV NDANKDEYVK LVCQMKMTGS IRKQLDAFLT GFYEIIPKDL ISMFNEQELE
LLISGLPTVD IDDMAANTDY KGFQKTSTHI QWFWRALRSF EKEDKAKFLQ FVTGTSKVPL
QGFASLEGMN GVQKFSIHMD SRGGDRLPAA HTCFNQLDLP QYESYEKLRQ SLLLAIRECT
EGFGFA
//
