ID E3R5U9_9LACO Unreviewed; 489 AA.
AC E3R5U9;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE Short=Gal-1-P uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE EC=2.7.7.12 {ECO:0000256|HAMAP-Rule:MF_00571};
DE AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
GN Name=galT {ECO:0000256|HAMAP-Rule:MF_00571,
GN ECO:0000313|EMBL:EFQ43886.1};
GN ORFNames=LBKG_01712 {ECO:0000313|EMBL:EFQ43886.1};
OS Lactobacillus crispatus CTV-05.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=440496 {ECO:0000313|EMBL:EFQ43886.1, ECO:0000313|Proteomes:UP000005124};
RN [1] {ECO:0000313|EMBL:EFQ43886.1, ECO:0000313|Proteomes:UP000005124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CTV-05 {ECO:0000313|EMBL:EFQ43886.1,
RC ECO:0000313|Proteomes:UP000005124};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease.;
RA Ward D., Xu Q., Earl A., Liu Y., Feldgarden M., Gevers D., Young S.K.,
RA Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D., Howarth C., Jen D., Larson L., Mehta T.,
RA Neiman D., Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lactobacillus crispatus strain CTV-05.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:66914; EC=2.7.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001107, ECO:0000256|HAMAP-
CC Rule:MF_00571};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 2 family. {ECO:0000256|ARBA:ARBA00008706, ECO:0000256|HAMAP-
CC Rule:MF_00571}.
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DR EMBL; GL531742; EFQ43886.1; -; Genomic_DNA.
DR RefSeq; WP_005719543.1; NZ_GL531742.1.
DR AlphaFoldDB; E3R5U9; -.
DR HOGENOM; CLU_047799_0_0_9; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000005124; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00571; GalP_UDP_trans; 1.
DR InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR NCBIfam; TIGR01239; galT_2; 1.
DR PANTHER; PTHR39191:SF1; DUF4922 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39191; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF006005; GalT_BS; 1.
DR PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00571};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00571}.
FT DOMAIN 17..223
FT /note="Galactose-1-phosphate uridyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01087"
FT DOMAIN 239..432
FT /note="Galactose-1-phosphate uridyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02744"
SQ SEQUENCE 489 AA; 55416 MW; 68CCE8D94E0F799A CRC64;
MKVIEKFADE VINSGAYEPL DRVYVINKIR ALVGDEASSV EANDEQTSVK QLVDLAVQNK
KISDDVTSRE VLNDQLYDLI TPTPSKTNGI FWQKMQKSPE KATDWFYKLC ENNNYVKKEA
IAKNVVFSGT SSKGHGLEIT INLSKPEKDP KAIAAAAHAT GKKYPQCALC LENEGYLGGY
GKNARSNLRI IRMNIGGRPW GFQYSPYAYF NEHCIFLDQK HIPMVINQQT LINLVEIEKT
LPHYFVGSNA DLPIVGGSML AHEHYQGGRH TFPMMKAKIK KNVVFDDYPE VVAGIVDWPM
SDLRLISDNS LDLIELGAKI INFWDHYSDS ARQIKAFDGK TRHHTVTPIM HREGKNFVLD
LVLRDNNTSE NYPLGIFHPH KELWHIKKEN IGLIEVMGRA ILPGRLKSEL EEVKKYWLGQ
DNKMAISHKE WADQIKAEQN ITAENVDAVM QQALVEVFEQ VLQDAGVFKN NADGDEGWDK
FITALTRQI
//
