ID E3T8Z9_9SAUR Unreviewed; 193 AA.
AC E3T8Z9;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ADD92293.1};
DE Flags: Fragment;
GN Name=NGFB {ECO:0000313|EMBL:ADD92293.1};
OS Oplurus cyclurus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Iguanidae; Oplurinae; Oplurus.
OX NCBI_TaxID=44149 {ECO:0000313|EMBL:ADD92293.1};
RN [1] {ECO:0000313|EMBL:ADD92293.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20930035; DOI=10.1093/sysbio/syq048;
RA Wiens J.J., Kuczynski C.A., Townsend T., Reeder T.W., Mulcahy D.G.,
RA Sites J.W.Jr.;
RT "Combining phylogenomics and fossils in higher-level squamate reptile
RT phylogeny: molecular data change the placement of fossil taxa.";
RL Syst. Biol. 59:674-688(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU432716; ADD92293.1; -; Genomic_DNA.
DR AlphaFoldDB; E3T8Z9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR020433; Venom_nerve_growth_factor.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR PRINTS; PR01917; VENOMNGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 120..193
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 9..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADD92293.1"
FT NON_TER 193
FT /evidence="ECO:0000313|EMBL:ADD92293.1"
SQ SEQUENCE 193 AA; 21796 MW; BE90A078D1E5E01D CRC64;
VLIGIWAAPK SEDNAPLGSP ATSDISESSR TKTRHVMKPT RHRDQNRPFV GKAEDRETGQ
ATNVFVDPKL FQKRRFQSPR VLFSTQPPPL SRDGQSVEFL DSTDSLNRNT RTKRATHPVH
NRGEYSVCDS VSVWVANKTT ATDIKGKQVT VMIDVNLNNN AYKQYFFETK CRDPKPVSSG
CRGIDARHWN SYC
//
