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Database: UniProt
Entry: E3TA32_RHIFL
LinkDB: E3TA32_RHIFL
Original site: E3TA32_RHIFL 
ID   E3TA32_RHIFL            Unreviewed;       195 AA.
AC   E3TA32;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:ADO30008.1};
DE   Flags: Fragment;
GN   Name=BMP2 {ECO:0000313|EMBL:ADO30008.1};
OS   Rhineura floridana (Florida worm lizard) (Lepidosternon floridanum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC   Lacertibaenia; Amphisbaenia; Rhineuridae; Rhineura.
OX   NCBI_TaxID=261503 {ECO:0000313|EMBL:ADO30008.1};
RN   [1] {ECO:0000313|EMBL:ADO30008.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20930035; DOI=10.1093/sysbio/syq048;
RA   Wiens J.J., Kuczynski C.A., Townsend T., Reeder T.W., Mulcahy D.G.,
RA   Sites J.W.Jr.;
RT   "Combining phylogenomics and fossils in higher-level squamate reptile
RT   phylogeny: molecular data change the placement of fossil taxa.";
RL   Syst. Biol. 59:674-688(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; GU457906; ADO30008.1; -; Genomic_DNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PRINTS; PR00669; INHIBINA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          103..195
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          95..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..116
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADO30008.1"
FT   NON_TER         195
FT                   /evidence="ECO:0000313|EMBL:ADO30008.1"
SQ   SEQUENCE   195 AA;  22330 MW;  2F61F749F151E788 CRC64;
     VQPEQEASTD PITRLLDTRL VHHNASKWET FDVTPAIMQW IAHGQPNHGF VVEVVHLDNE
     SSVSKRHVRI SRSLHQDDXS WSRIRPLLVT FGHDGKGHPL HKREKRQAKH KQRKRKSNCK
     RHXLYVDFND VGWNDWIVAP PGYSAFYCHG DCPFPLADHL NSTNHAIVQT LVNSVNSKIP
     KACCVPTXLX PIFML
//
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