ID E3V2E3_MACFA Unreviewed; 418 AA.
AC E3V2E3;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Vasopressin V1a receptor {ECO:0000256|ARBA:ARBA00021173, ECO:0000256|RuleBase:RU046427};
GN Name=AVPR1A {ECO:0000313|EMBL:ADO79885.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:ADO79885.1};
RN [1] {ECO:0000313|EMBL:ADO79885.1}
RP NUCLEOTIDE SEQUENCE.
RA Thompson D.J., Qi S.Y., Vezza Alexander R., Croston G.E.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC {ECO:0000256|RuleBase:RU046427}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily.
CC {ECO:0000256|RuleBase:RU046427}.
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DR EMBL; HM856594; ADO79885.1; -; mRNA.
DR RefSeq; NP_001306296.1; NM_001319367.1.
DR AlphaFoldDB; E3V2E3; -.
DR OrthoDB; 2879183at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15385; 7tmA_V1aR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24241:SF17; VASOPRESSIN V1A RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; V1R_C; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU046427};
KW Glycoprotein {ECO:0000256|RuleBase:RU046427};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU046427};
KW Receptor {ECO:0000256|RuleBase:RU046427, ECO:0000313|EMBL:ADO79885.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU046427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU046427};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU046427}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 88..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 219..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT DOMAIN 68..348
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 377..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 46973 MW; 0DAC4FC4D7A22608 CRC64;
MRFSAGPDAG RSGNSSLWWP LATSAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV
TFTVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP
DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV
LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC
YNIWRNVRGK TASRQSKGAE QAGAAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
IVCWAPFFII QMWSVWDPKS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV
QSFPCCQNIK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFLPVST
//
