ID   E4NB52_KITSK            Unreviewed;       526 AA.
AC   E4NB52;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=chitinase {ECO:0000256|ARBA:ARBA00012729};
DE            EC=3.2.1.14 {ECO:0000256|ARBA:ARBA00012729};
GN   Name=chiA2 {ECO:0000313|EMBL:BAJ28433.1};
GN   OrderedLocusNames=KSE_26210 {ECO:0000313|EMBL:BAJ28433.1};
OS   Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS   / NBRC 14216 / KM-6054) (Streptomyces setae).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Kitasatospora.
OX   NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ28433.1, ECO:0000313|Proteomes:UP000007076};
RN   [1] {ECO:0000313|EMBL:BAJ28433.1, ECO:0000313|Proteomes:UP000007076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC   KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX   PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA   Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA   Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA   Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA   Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA   Takahashi Y., Fujita N.;
RT   "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT   snapshot of the family Streptomycetaceae.";
RL   DNA Res. 17:393-406(2010).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family.
CC       {ECO:0000256|RuleBase:RU004453}.
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DR   EMBL; AP010968; BAJ28433.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4NB52; -.
DR   STRING; 452652.KSE_26210; -.
DR   CAZy; CBM16; Carbohydrate-Binding Module Family 16.
DR   CAZy; GH18; Glycoside Hydrolase Family 18.
DR   KEGG; ksk:KSE_26210; -.
DR   PATRIC; fig|452652.3.peg.2627; -.
DR   eggNOG; COG3469; Bacteria.
DR   HOGENOM; CLU_019399_1_1_11; -.
DR   Proteomes; UP000007076; Chromosome.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0004568; F:chitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd02871; GH18_chitinase_D-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR45708; ENDOCHITINASE; 1.
DR   PANTHER; PTHR45708:SF49; ENDOCHITINASE; 1.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS01095; GH18_1; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000489};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000489};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007076}.
FT   DOMAIN          233..521
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
FT   REGION          179..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..204
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  53428 MW;  0C2653FEC9288770 CRC64;
     MRALPPPPPP RPRTGRVLLA GLLSASVGLV GLTLAGSGTA TADVAPNVNV VANGDFAAGN
     HISPWTCGPT VTAVNNTATG WDLQGAPAGN DYANCSQSVT VLPNSTYTLS AVVQGGYVFA
     GVTGTGGTDP STWSSNAGWN TLTSTFTTGA STTSVSVWFH GWYGQTPFTV DKVSLVGPGT
     APGSPSPTPT IIVDPTPSPS QSSPKPSPSV TEGTPTGSTS PSGSPTAPPP RKHLLTGYWQ
     DFYNGATPQR ISDVPAAYDI IAVAFADATS TRGGLSFTLD PTLSSKLGGY TEAQFKADIA
     AKRAAGKKVI ISVGGQNGTV SVSDSASATT FANSAYSLIQ QYGFDGIDID LENGVNATYM
     SQALHSLAAK VGSGFVLTMA PETIGMQSTG GEYFKLALAT KDILTIVNMQ YYNSGAMLGC
     DGGVYSQGTE NFLTGLACIQ LQGGLRPDQV GLGVPASTSA AGGGYISPAT VNNALDCLAS
     GTNCGSFKPS QTWPTIGGAM TWSTNWDATA GNQIANTIGA HLHAMP
//