ID E4NRU7_HALBP Unreviewed; 1152 AA.
AC E4NRU7;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=Hbor_13010 {ECO:0000313|EMBL:ADQ66884.1};
GN ORFNames=C499_03958 {ECO:0000313|EMBL:ELY30391.1};
OS Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 /
OS KCTC 4070 / PR3).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Halogeometricum.
OX NCBI_TaxID=469382 {ECO:0000313|EMBL:ADQ66884.1, ECO:0000313|Proteomes:UP000006663};
RN [1] {ECO:0000313|EMBL:ADQ66884.1, ECO:0000313|Proteomes:UP000006663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3
RC {ECO:0000313|Proteomes:UP000006663}, and PR 3
RC {ECO:0000313|EMBL:ADQ66884.1};
RX PubMed=21304651; DOI=10.4056/sigs.23264;
RA Malfatti S., Tindall B.J., Schneider S., Fahnrich R., Lapidus A.,
RA Labuttii K., Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S.,
RA Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Anderson I.,
RA Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA D'haeseleer P., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Chain P.;
RT "Complete genome sequence of Halogeometricum borinquense type strain
RT (PR3).";
RL Stand. Genomic Sci. 1:150-159(2009).
RN [2] {ECO:0000313|EMBL:ELY30391.1, ECO:0000313|Proteomes:UP000011585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11551 {ECO:0000313|EMBL:ELY30391.1,
RC ECO:0000313|Proteomes:UP000011585};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001690; ADQ66884.1; -; Genomic_DNA.
DR EMBL; AOHT01000010; ELY30391.1; -; Genomic_DNA.
DR RefSeq; WP_006054110.1; NZ_AOHT01000010.1.
DR AlphaFoldDB; E4NRU7; -.
DR STRING; 469382.Hbor_13010; -.
DR GeneID; 9993120; -.
DR KEGG; hbo:Hbor_13010; -.
DR PATRIC; fig|469382.19.peg.784; -.
DR eggNOG; arCOG00802; Archaea.
DR HOGENOM; CLU_268118_0_0_2; -.
DR OrthoDB; 203178at2157; -.
DR Proteomes; UP000006663; Chromosome.
DR Proteomes; UP000011585; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:ADQ66884.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000006663}.
FT DOMAIN 19..434
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 435..716
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1152 AA; 128010 MW; 8AEE5D245CCE06E9 CRC64;
MSGDSDEYPL WYPVPEEDVS PEPQQETIID SDAYPMRVLA GAGTGKTFTM VRKVEHLIDE
EDVSPDRILT LTFTNNAAGS MREKLNAKLG TAGYDIDAYT YHSICNEILT DYAYEAGIDP
DFEVATDAEK YAIVLDVLDD IEYRSVKPNV YGSDGYASGA ASKLLNFIGS MKRSGITPDD
IDAFLGPADR VYELADLSER VEAIASDHLG GRSVSSVLDS LPDVRADLVE ERDVLGMDGM
EASVRDFLDR LVDLCDALEA AFEAHEAGDR DLPDNAYKLP KYLLGGYANG APKGIPGDLD
LELTDHLDSF LSDCLTARDL TAGYAAYERE LDERNLIDFD GLVVEAAELM ESPVGEEIAA
RWDYVFCDEF QDTDRLQFDL VKSLVTDDNL FVVGDDDQAI YEWRGAHVAN ITDELDRAFA
ALSDEPLEEN FRSRQPILDL ANEAIQKLDH RERHKTLKRV DEPEYDGDTI ATVELSDEDD
ADGASQLRTV VQNLLSGAAE SFDEAYDPGD IALLVRKNDH ATPVIEEFED AGIPYQVAGD
LATESVGVGT VTAYLKALAR PEDEVSWNRV LLMRYRLCDT DLRKLNAGDD PLVDTLRETP
LDEFEEPDRV AEARKHVTEL LAIRDSASLS HLYRELTDVT NIEWYLSEQE RRDLAQLEDV
IEQYGDSAVQ PPLTPEFIDS LEHYDSLFDE SGSSPTSQPD VADDAVNVMT IHKSKGLDFP
VVLIPQVTAG EWAPSSRTYD ALETSLSDGA EAAFAEDFVE RDARETRRVF HVGITRAEDV
LVLQGGSEDD DATDVHPVSE SVDEILPSRI PWQPERGQLP LWADVQDCLP REAVDWTDTL
ATETVGHVGG TVNHAGEELA VAAARDRVLD LATATLNGEL SPRAERETLQ VASLTDPSTP
SPSLSHSYTS LAAYEECPRS HYLDYVVNAF PDYQETTVRS DSGGGVSQRE IGLLFHDTAE
QAAKQGVKRR GDWYEICERL ASHRRAEDAL TAAKECIDRY FELELPNCEI IDAEREFELD
IDGHELVGYI DAVYRTPDDG LLVIDYKATE RHRDLEDDKQ LPIYLLACCD LYDEPVTRAG
YAYVGEIGPK VETRTFSDAD LEAVTDDVTE SMTRISEFSF NRYSADEHCQ WCQHNQLPCA
PDSFSVGPRS EE
//
