ID E4NSW6_HALBP Unreviewed; 440 AA.
AC E4NSW6;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=OAH/OAS sulfhydrylase {ECO:0000313|EMBL:ADQ65854.1, ECO:0000313|EMBL:ELY26856.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:ADQ65854.1};
GN OrderedLocusNames=Hbor_02440 {ECO:0000313|EMBL:ADQ65854.1};
GN ORFNames=C499_11636 {ECO:0000313|EMBL:ELY26856.1};
OS Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 /
OS KCTC 4070 / PR3).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Halogeometricum.
OX NCBI_TaxID=469382 {ECO:0000313|EMBL:ADQ65854.1, ECO:0000313|Proteomes:UP000006663};
RN [1] {ECO:0000313|EMBL:ADQ65854.1, ECO:0000313|Proteomes:UP000006663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3
RC {ECO:0000313|Proteomes:UP000006663}, and PR 3
RC {ECO:0000313|EMBL:ADQ65854.1};
RX PubMed=21304651; DOI=10.4056/sigs.23264;
RA Malfatti S., Tindall B.J., Schneider S., Fahnrich R., Lapidus A.,
RA Labuttii K., Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S.,
RA Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Anderson I.,
RA Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA D'haeseleer P., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Chain P.;
RT "Complete genome sequence of Halogeometricum borinquense type strain
RT (PR3).";
RL Stand. Genomic Sci. 1:150-159(2009).
RN [2] {ECO:0000313|EMBL:ELY26856.1, ECO:0000313|Proteomes:UP000011585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11551 {ECO:0000313|EMBL:ELY26856.1,
RC ECO:0000313|Proteomes:UP000011585};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077}.
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DR EMBL; CP001690; ADQ65854.1; -; Genomic_DNA.
DR EMBL; AOHT01000037; ELY26856.1; -; Genomic_DNA.
DR RefSeq; WP_006055635.1; NZ_AOHT01000037.1.
DR AlphaFoldDB; E4NSW6; -.
DR STRING; 469382.Hbor_02440; -.
DR GeneID; 9992064; -.
DR KEGG; hbo:Hbor_02440; -.
DR PATRIC; fig|469382.19.peg.2289; -.
DR eggNOG; arCOG00061; Archaea.
DR HOGENOM; CLU_018986_4_0_2; -.
DR OrthoDB; 43458at2157; -.
DR Proteomes; UP000006663; Chromosome.
DR Proteomes; UP000011585; Unassembled WGS sequence.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000006663};
KW Transferase {ECO:0000313|EMBL:ADQ65854.1}.
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 46956 MW; 1FC2FCCDC9FF9327 CRC64;
MNHGFHTRSL HAGQEPDAAT GSRAPPLYQT TSYVFEDADY AADLYALDAE GDVYSRISNP
TTRVLEDRLA ALEAGVGAVA TASGMAALDA ATSLLASAGD NVVASADMYG GTSTYLTKMA
TRRGVDIRVV ETLDYDAYAD AIDADTAFVH VETIANPSLK TPDFERLAHV AHEGGAPLVV
DNTFATPYLC RPIEHGADIV WESTTKWLHG SGTTVGGVLI DGGTFPWEHA DYDELSGENP
AFGVDFVERF GERAFAMAAR QRSLRTLGNQ QSPFDAWQTL QGIETLPLRM EQHCENAHEV
ATFLRDHDDV AWVSYPGFED HESHDNATEY LDGGFGGMVT FGLADGYAAA KRTCENTALA
SFLANVGDAK TLIIHPASTT HAQLSADEQR AAGVGPDMLR LSVGIEDAAD IVADLDESIR
SAAAEASGAG ATETTRTEER
//
