ID E4PYM9_STAAU Unreviewed; 599 AA.
AC E4PYM9; A0A516UZB9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Beta-lactamase regulator protein {ECO:0000313|EMBL:ADM29175.1};
DE SubName: Full=BlaR-1 {ECO:0000313|EMBL:AIU96715.1};
GN Name=blaRI {ECO:0000313|EMBL:BAM37197.1};
GN ORFNames=SUO_0016p2 {ECO:0000313|EMBL:ADM29175.1};
OS Staphylococcus aureus.
OG Plasmid p1070 {ECO:0000313|EMBL:QDQ71453.1},
OG Plasmid p19321-P03 {ECO:0000313|EMBL:ADM29175.1},
OG Plasmid p2-1850 {ECO:0000313|EMBL:QDQ71432.1},
OG Plasmid p2575 {ECO:0000313|EMBL:QDQ71477.1},
OG Plasmid p4456 {ECO:0000313|EMBL:QDQ71500.1},
OG Plasmid p4578 {ECO:0000313|EMBL:QDQ71411.1},
OG Plasmid p6092 {ECO:0000313|EMBL:QDQ71521.1},
OG Plasmid p6306 {ECO:0000313|EMBL:QDQ71544.1},
OG Plasmid p6414-1 {ECO:0000313|EMBL:QDQ71563.1},
OG Plasmid p6530 {ECO:0000313|EMBL:QDQ71588.1},
OG Plasmid p7601 {ECO:0000313|EMBL:QDQ71607.1}, and
OG Plasmid pBU108b {ECO:0000313|EMBL:AIU96715.1}.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:ADM29175.1};
RN [1] {ECO:0000313|EMBL:ADM29175.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=19321 {ECO:0000313|EMBL:ADM29175.1};
RC PLASMID=p19321-P03 {ECO:0000313|EMBL:ADM29175.1};
RX PubMed=20943864; DOI=10.1128/JCM.01050-10;
RA Kennedy A.D., Porcella S.F., Martens C., Whitney A.R., Braughton K.R.,
RA Chen L., Craig C.T., Tenover F.C., Kreiswirth B.N., Musser J.M.,
RA Deleo F.R.;
RT "Complete nucleotide sequence analysis of plasmids in strains of
RT Staphylococcus aureus clone USA300 reveals a high level of identity among
RT isolates with closely related core genome sequences.";
RL J. Clin. Microbiol. 48:4504-4511(2010).
RN [2] {ECO:0000313|EMBL:BAM37197.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PM1 {ECO:0000313|EMBL:BAM37197.1};
RX PubMed=23071689; DOI=10.1371/journal.pone.0046987;
RA Hung W.-C., Takano T., Higuchi W., Iwao Y., Khokhlova O., Teng L.-J.,
RA Yamamoto T.;
RT "Comparative Genomics of Community-Acquired ST59 Methicillin-Resistant
RT Staphylococcus aureus in Taiwan: Novel Mobile Resistance Structures with
RT IS1216V.";
RL PLoS ONE 7:e46987-e46987(2012).
RN [3] {ECO:0000313|EMBL:AIU96715.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A960649 {ECO:0000313|EMBL:AIU96715.1};
RC PLASMID=pBU108b {ECO:0000313|EMBL:AIU96715.1};
RA Utter B.D., Schuch R., Winer B.Y., Verratti K., Bishop-Lilly K.,
RA Sozhamannan S., Fischetti V.A.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AIU96715.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A960649 {ECO:0000313|EMBL:AIU96715.1};
RC PLASMID=pBU108b {ECO:0000313|EMBL:AIU96715.1};
RX PubMed=24963913;
RA Utter B., Deutsch D.R., Schuch R., Winer B.Y., Verratti K.,
RA Bishop-Lilly K., Sozhamannan S., Fischetti V.A.;
RT "Beyond the Chromosome: The Prevalence of Unique Extra-Chromosomal
RT Bacteriophages with Integrated Virulence Genes in Pathogenic Staphylococcus
RT aureus.";
RL PLoS ONE 9:E100502-E100502(2014).
RN [5] {ECO:0000313|EMBL:QDQ71411.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=p1070 {ECO:0000313|EMBL:QDQ71453.1}, p2-1850
RC {ECO:0000313|EMBL:QDQ71432.1}, p2575 {ECO:0000313|EMBL:QDQ71477.1},
RC p4456 {ECO:0000313|EMBL:QDQ71500.1}, p4578
RC {ECO:0000313|EMBL:QDQ71411.1}, p6092 {ECO:0000313|EMBL:QDQ71521.1},
RC p6306 {ECO:0000313|EMBL:QDQ71544.1}, p6414-1
RC {ECO:0000313|EMBL:QDQ71563.1}, p6530 {ECO:0000313|EMBL:QDQ71588.1},
RC and p7601 {ECO:0000313|EMBL:QDQ71607.1};
RA Hung W.-C.;
RT "Beta-lactamase-producing plasmid of ST59 Staphylococcus aureus.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M56 family.
CC {ECO:0000256|ARBA:ARBA00011075}.
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DR EMBL; CP002147; ADM29175.1; -; Genomic_DNA.
DR EMBL; KF831356; AIU96715.1; -; Genomic_DNA.
DR EMBL; AB699881; BAM37197.1; -; Genomic_DNA.
DR EMBL; MK933268; QDQ71411.1; -; Genomic_DNA.
DR EMBL; MK933269; QDQ71432.1; -; Genomic_DNA.
DR EMBL; MK933270; QDQ71453.1; -; Genomic_DNA.
DR EMBL; MK933271; QDQ71477.1; -; Genomic_DNA.
DR EMBL; MK933272; QDQ71500.1; -; Genomic_DNA.
DR EMBL; MK933273; QDQ71521.1; -; Genomic_DNA.
DR EMBL; MK933274; QDQ71544.1; -; Genomic_DNA.
DR EMBL; MK933275; QDQ71563.1; -; Genomic_DNA.
DR EMBL; MK933276; QDQ71588.1; -; Genomic_DNA.
DR EMBL; MK933277; QDQ71607.1; -; Genomic_DNA.
DR RefSeq; YP_006958140.1; NC_019148.1.
DR RefSeq; YP_006958594.1; NC_018976.1.
DR AlphaFoldDB; E4PYM9; -.
DR MEROPS; M56.001; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR008756; Peptidase_M56.
DR PANTHER; PTHR30627:SF6; BETA-LACTAMASE YBXI-RELATED; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF05569; Peptidase_M56; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:ADM29175.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..312
FT /note="Peptidase M56"
FT /evidence="ECO:0000259|Pfam:PF05569"
FT DOMAIN 381..590
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 599 AA; 70723 MW; 8ED113BF28ECD707 CRC64;
MSIVYYKYLK EGVKMAKLLI TSVVSFCFIF LLLVFFKYIL KRYFNYSLNY KVWYLTVLAG
LIPFIPIKFS FIKLNNVNNQ APTVESKSHD LNHNINTTKP VQEFTTDIHK FNWDSIDNIC
TVVWIVLVII LSFKFLKSLL YLKYLKKQSL YLNENEKNKI DTILFNHQYK KNIVIRKAET
IQSPITFWYG KYIILIPSSY FKSVIDKRLK YIILHEYAHA KNRDTLHLII FNIFSIVMSY
NPLIHIVKRK IIHDNEVEAD RFVLNNINKN EFKTYAESIM DSVLNIPFFN KNILSHSFNG
KKSLLKRRLI NIKEANLKKQ SKLIPIFICI FTFLLMVIQS QFLMGQSITD YNYKKPLQND
HQILDESKNF GSNSGSFVMY SMKKDKYYIY NEKESRKRYS PDSTYKIYLA MFGLDHHIIS
DKNSRMSWNH KHYPFESWNK EQDLNTAMQN SVNWYFERIS NQIPKNYTAA QLKQLNYGNE
NLGSYKSYWM EDSLKISNLE QVIVFKNMME QNNHFSKKAK NQLSSSLLIK KNEKYELYGK
TGTGIVNGKY NNGWFVGYVI TNHDKYYFAT HLSDGKPSGK NAELISEKIL KEMGVLNGQ
//
