ID E4RKQ8_HALHG Unreviewed; 379 AA.
AC E4RKQ8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=rRNA (Guanine-N(2)-)-methyltransferase {ECO:0000313|EMBL:ADQ14728.1};
DE EC=2.1.1.171 {ECO:0000313|EMBL:ADQ14728.1};
GN OrderedLocusNames=Halsa_1301 {ECO:0000313|EMBL:ADQ14728.1};
OS Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ14728.1, ECO:0000313|Proteomes:UP000007434};
RN [1] {ECO:0000313|EMBL:ADQ14728.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT "Complete sequence of Halanaerobium sp. sapolanicus.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ14728.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX PubMed=21602336; DOI=10.1128/JB.05209-11;
RA Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT Halanaerobium hydrogenoformans.";
RL J. Bacteriol. 193:3682-3683(2011).
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DR EMBL; CP002304; ADQ14728.1; -; Genomic_DNA.
DR RefSeq; WP_013405809.1; NC_014654.1.
DR AlphaFoldDB; E4RKQ8; -.
DR STRING; 656519.Halsa_1301; -.
DR KEGG; has:Halsa_1301; -.
DR eggNOG; COG0116; Bacteria.
DR HOGENOM; CLU_032119_3_1_9; -.
DR OrthoDB; 9809404at2; -.
DR Proteomes; UP000007434; Chromosome.
DR GO; GO:0052913; F:16S rRNA (guanine(966)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR47313; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR PANTHER; PTHR47313:SF1; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ADQ14728.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007434};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000313|EMBL:ADQ14728.1}.
FT DOMAIN 45..155
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 379 AA; 43428 MW; AD44FACFF98E2E63 CRC64;
MTNLSIIASS TFGMEALVKK EIKKLGYEIT EVKNGRITFT GDLKAVAEAN LWLRTAERVM
IKIGEFEALD FDQLYEGVKA LDWPKWLPEN AEFPVSGKSI DSQLSSVPTC QSVVKKAVVD
SMKEKYGDQW FPEDGPLYPI EIALYKDQAL LTIDSSGTGL HKRGYRDLTV TAPIQETIAA
GMIYLSRWDK DRILIDPFCG SGTILIEAAM IAKNQAPGLK RNFISEKWPI FDNMLWAKTR
VEAKKAKKID VEPRLIMGYD HDPEAISIAR YHAKKAGVDD LIHFQEKKFE DFSSSRKYGY
IITNPPYGKR MSDQEEVEAL YKKMGEKFRD LDTWSYYIIT SHPNFEEIFA KEADKRRKLY
SGGMETHYYQ YYGPWPPKN
//
