ID E4UDC1_LIBSC Unreviewed; 1185 AA.
AC E4UDC1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN OrderedLocusNames=CKC_03060 {ECO:0000313|EMBL:ADR52361.1};
OS Liberibacter solanacearum (strain CLso-ZC1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Liberibacter.
OX NCBI_TaxID=658172 {ECO:0000313|EMBL:ADR52361.1, ECO:0000313|Proteomes:UP000007038};
RN [1] {ECO:0000313|Proteomes:UP000007038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLso-ZC1 {ECO:0000313|Proteomes:UP000007038};
RA Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y., Zhou L.,
RA Glynn J.;
RT "Complete genome sequence of Candidatus Liberibacter solanacearum CLso-
RT ZC1.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CLso-ZC1;
RA Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y., Zhou L.,
RA Glynn J.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ADR52361.1, ECO:0000313|Proteomes:UP000007038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLso-ZC1 {ECO:0000313|EMBL:ADR52361.1,
RC ECO:0000313|Proteomes:UP000007038};
RX PubMed=21552483; DOI=10.1371/journal.pone.0019135;
RA Lin H., Lou B., Glynn J.M., Doddapaneni H., Civerolo E.L., Chen C.,
RA Duan Y., Zhou L., Vahling C.M.;
RT "The Complete Genome Sequence of 'Candidatus Liberibacter solanacearum',
RT the Bacterium Associated with Potato Zebra Chip Disease.";
RL PLoS ONE 6:E19135-E19135(2011).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP002371; ADR52361.1; -; Genomic_DNA.
DR RefSeq; WP_013462017.1; NC_014774.1.
DR AlphaFoldDB; E4UDC1; -.
DR STRING; 658172.CKC_03060; -.
DR KEGG; lso:CKC_03060; -.
DR eggNOG; COG1197; Bacteria.
DR HOGENOM; CLU_005122_3_1_5; -.
DR Proteomes; UP000007038; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 639..800
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 821..975
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1185 AA; 134226 MW; 6303EEDCF9A28E4E CRC64;
MIFGDYINKI NEKPCKKITL SQVFPGTEPF VLAEIARSGL SLVYIGSDER ALVNIKKTLA
FIVPDIDVII FPAWDCLPYD RISASPRVVT DRLACFSHLI SCNPSKKTSI ILTTVSAVMC
RSVNFMSIKD CKFSIQSKDQ ISMAKVIEKL EKNGFQRVNT VYKVGEYAVR GGILDVYGPS
EKYPVRLDFF GDTIESLRLF DYASQRTIRE ISTFTINTLS EVVLTSENIS LFRKNYLLNF
GAATQKDLLY VTVSQGNRYP GMEHWLPFFY QKMETIFSYL ADFCIVTDSA VKDTAHKRSQ
LIQDYYEARC QHSSDKKNYS IYKPILPEKL YLTYQQFEAM LESSNKLIQM TPFSQQETSH
SCVVCLNVRP GKSWVPSAVQ KIESQENWES MNRFDRFLSY VAQQFQKGKK AFIAASSKGA
LQHLIHLMES DGLNKIKKID CFNEIHSLAK EEIAAAVLPI DQGFETGNMI LVTEKDLLGK
RIIRRTVRKS SLANSFFESS NIEEGSIIVH AEHGIGRFIR LSSIEVSGTS HDCLELHYAD
NAKLFVPVEN IDLISQYSTE NETIMLDKLG GSSWQSRKSN LKKRLEDLAQ KLVDIAAKRL
IHNVPALTVS QDLYSQFVKK FPHVETEDQE KAVDAVIQDF TSGHLMDRLI CGDVGFGKTE
IALRAAFIAV MNGLQVAVIA PTTLLVRQHF RLFSERFQDF PVRIVSVSRF VKPKEVALHK
KAIAEGQVDI VIGTHALLDP KITFSNLGLI IVDEEQHFGV KHKEALKETH TGVHVLTLSA
TPIPRTLQLA ITGVRELSLI SMPPINRIAC RTSISIFDPL LIRETLMREY YRGGQSFYVC
PRLLDLDKCY DFLQSEVPEL KVAMAHGQMS PKNLEETMNG FYERKYDILL STSIVESGLD
LPNANTIIIQ RADMFGLAQL YQLRGRVGRS KISSFALFLL PENKPLTSSA QKRLRILQSL
NTLGAGFQLA SHDLDIRGTG NLLGEEQSGH IKEVGFELYQ KMLGETVASI KGKRELVDSD
WSPQIMIEAS VMIPDSYVSD VNLRLSLYRR LGNITDHTDI NRFKEEMVDR FGSLPIEVVH
LLKVLFLKLL CRIANIEKMD IGPKGIIVQF RNKKFHNPEK LLQYIMQQKG KIIIRPDQSL
FFDCLLPTIN KRFIEAKHIL SQLIKLIDVD IQKCDKNDSA SLKVK
//
