ID E4UNH5_ARTGP Unreviewed; 838 AA.
AC E4UNH5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MGYG_02595 {ECO:0000313|EMBL:EFQ99583.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; DS989823; EFQ99583.1; -; Genomic_DNA.
DR RefSeq; XP_003175066.1; XM_003175018.1.
DR AlphaFoldDB; E4UNH5; -.
DR STRING; 535722.E4UNH5; -.
DR GeneID; 10030371; -.
DR VEuPathDB; FungiDB:MGYG_02595; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_0_0_1; -.
DR InParanoid; E4UNH5; -.
DR OMA; QGIGMFP; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..194
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 216..420
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 432..709
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 757..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 95783 MW; 3B436A8FC0F1983E CRC64;
MTSQLPLPAA TTTRALVYAF ATNQPDGPRY QDQTRGQRDL LTQIVISVGF GLSAFITFCF
LRPKWSALYA ARRKMRTAAS RLPDLPDSLF GWIPVLFKIS DEEVLASGGL DAFVFLLFYK
YSIHFLSIVF FFSVVVILPV RYSYTGERGY PWDGDRGEQP GGDSDKKPKT DPTFLWLYVV
FSYVFTGVAV HLLISYTNRV IQIRQKCLGG QTTMADRTIR LSGIPVDLQS EEKIQDFIEG
LEIGNVESVM LCRDWRELDR LMEERKCTLQ RLEESWAKYL RYRKSKPRGV LPSRANRISP
QIDTADTSES ARLLSDEPNT HQNHIFENPG ARPRIRIWFG PLKIQFKSID AIDYYEEKLR
HLDEKIEIAR QQECTPGALA FVTMESIAAC QMAVQAILDP WPMQLVANLA PAPADVVWQH
TYMSRTERMI RGWTITTVIC VLTIFWSLLL VPLAYLLNLE TLEKVIPRLA EVLSEHPLLR
SLMQTGLPTL TLSLLSLAVP YIYDWLANVQ GMTSQGDVEL SVISKNFFFT FFNLFLVFTV
FATASNFYGL WENLRDVFKD TTTIAFALAR SLEKLAPFYT NLIVLQGLGL FPFRLLEFGS
VFLYPFQRMF AVTPRDYADL RKPPTFSYGF ALPPTILIFI VCLVYSVFPS SWLVCLFGLI
YFSIGQFIYK YQLLYAMDHQ QHSTGRAWPM ICSRIILGLV VFQLTMIGSL ALRSAITRSI
LIIPLLAATV WFSYFFTRTY EPLMKFIALR SIDRHRDADN DQSPTPSSNF SPPSQWDRDA
IPLRLRGRDI TPRLRKYINP NLVIPLDSAW IPGQPENYDN DVTSFSQNGI SVVDHEAV
//