ID E4V241_ARTGP Unreviewed; 356 AA.
AC E4V241;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Homoserine acetyltransferase {ECO:0000313|EMBL:EFR04106.1};
GN ORFNames=MGYG_07113 {ECO:0000313|EMBL:EFR04106.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MetX family.
CC {ECO:0000256|ARBA:ARBA00006886}.
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DR EMBL; DS989827; EFR04106.1; -; Genomic_DNA.
DR RefSeq; XP_003171114.1; XM_003171066.1.
DR AlphaFoldDB; E4V241; -.
DR STRING; 535722.E4V241; -.
DR GeneID; 10026363; -.
DR VEuPathDB; FungiDB:MGYG_07113; -.
DR eggNOG; ENOG502QVPA; Eukaryota.
DR HOGENOM; CLU_028760_2_0_1; -.
DR InParanoid; E4V241; -.
DR OMA; KLGDWEL; -.
DR OrthoDB; 5489509at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR008220; HAT_MetX-like.
DR PANTHER; PTHR32268:SF15; HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350); 1.
DR PANTHER; PTHR32268; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF000443; Homoser_Ac_trans; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transferase {ECO:0000313|EMBL:EFR04106.1}.
FT DOMAIN 61..141
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT ACT_SITE 123
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT ACT_SITE 294
FT /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT ACT_SITE 325
FT /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
SQ SEQUENCE 356 AA; 39958 MW; 0D203D35F5BA8B4A CRC64;
MSEEYDTFGL GDWTLQSGDV IPKARIAYRT FGDPKLPAIV YPSWYSGTIS ANFWLIGEDM
ELNPKKYFII IPALFGNGQS SSPSNTDLSP FPAVSVYDNV RAQYKLVTEH LGVKHLRAVL
GWSMGAGQTF QWAVQYPDFM DIAVPFCGSA KTSLHNKVFL EGVKSALLSA KRFRSAGSGK
DGICSEGVVA RKWTEEERDI GLRAVGRVYA GWGMSQSFYR EKLYETVLGY KDLEDFLVNF
WEKYFLSKDP ENLLVMLRTW QNADVSQQEP YHGNFEKALG GIKAKTLVLP CKHDLYFPPE
DSEYEVANMA PGVGELGVFP SIWGHWAGGP GESKEDVKWL NNKLVELFKK VPVRDS
//
