ID   E4V9F5_BIFBI            Unreviewed;      1195 AA.
AC   E4V9F5;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=BBNG_00795 {ECO:0000313|EMBL:EFR50247.1};
OS   Bifidobacterium bifidum NCIMB 41171.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=398513 {ECO:0000313|EMBL:EFR50247.1, ECO:0000313|Proteomes:UP000002776};
RN   [1] {ECO:0000313|EMBL:EFR50247.1, ECO:0000313|Proteomes:UP000002776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCIMB 41171 {ECO:0000313|EMBL:EFR50247.1,
RC   ECO:0000313|Proteomes:UP000002776};
RG   The Broad Institute Genome Sequencing Platform;
RA   Goulas T., Tzortzis G., Gibson G.R., Ward D., Mehta T., Young S., Jaffe D.,
RA   Gnerre S., Berlin A., Heiman D., Hepburn T., Shea T., Sykes S.,
RA   Alvarado L., Kodira C., Borodovsky M., Lander E., Galagan J., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Bifidobacterium bifidum strain NCIMB 41171.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; DS990229; EFR50247.1; -; Genomic_DNA.
DR   RefSeq; WP_003812956.1; NZ_DS990229.1.
DR   AlphaFoldDB; E4V9F5; -.
DR   GeneID; 56627294; -.
DR   eggNOG; COG0827; Bacteria.
DR   eggNOG; COG1002; Bacteria.
DR   HOGENOM; CLU_007510_1_0_11; -.
DR   Proteomes; UP000002776; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR047939; BREX_1_PglX.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          311..517
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
SQ   SEQUENCE   1195 AA;  136258 MW;  EE5BD47CD8CA92C9 CRC64;
     MNTSKLQAFA TDARRQLMNA VRARLDAALV PNSDAQVDDP RAFDFLQREI ERAGDGEEGR
     RHVVERYAYR WFNRIVAFRY MDVHGFTGTP VVSPAGLTST NGLPEVLAAA KRGEYDSRVF
     SAHVNDKAKE RIEGLLSGSI LADDPQGVAY GLLLQSECRF WNRNLPFVFE NVGKEAGRVD
     ELLMPADLLA EGSVLRNAVE VMTPEDCGVD DPSGNVEIIG WLYQYYISER KNEVMDGFKK
     NHKAGAEEIP AATQLFTPDW IVRYLVQNTV GRLWMQSHPD SQLYKNWDYY IQPSEDGSTE
     NEDILNIQTP EELTVCDPAC GSGHMLTYAF DLLYEIYEEE GYAPSDIPGL ILKHNLYGME
     IDERAASLAA FALTMKARSR SRRFFKKQVE PNIQRIVPIS FEESDVVDLN DLYQVDLDFT
     VWNTYAKADV YGSLIEPPQE LVDLAASAED AEAETTLFDS LLRERVEGVF AQTRYLARKY
     AAVVANPPYM GAKNMSGELK QFVQDRYEDG KADLFAAFIY RLLGMVPEHG QLGFMTPYVW
     MFISSYEQMR QHIIRQEHIS SLIQLEYSGF EGATVPICTF TLEKGHSDRK SAFVRLSDFV
     GAKQQGPRAL GIIDAHNNEQ SAHSGMRKYF FEVNQHEFAQ IPGSPIVYWL GEQLRKTLIN
     PASDTILFSD GLIKTGDNLQ YLRLWWELIS TNVNNKSRYR FCAKGGKERN YYGNLNNVVK
     WDEETRDYYR SDKVARISPK YLWDKEGITW TKISSRGGTF RLLRKEDIAE TGGPSLFLKD
     NVDGNDLLSF IGVITSSLAP YILQGLNPTL NYQTGDVLRF PLPIKKEEAL PSLVHSMIGS
     SKEDWDSFET SWDFQRFALL DPNQGSQAGD LLEDAVTHLR EYWNRVSEEQ RQREIRNNEL
     VADAYGVRDD VPCDVPLERV SLKRNVAFAY PKDTPEARNE KFAQDVVREL ISYAVGCMFG
     RYSLNKPGLI LASQGETLDD FHAQIPNPSF EPDVDNVIPV TETDCFEDDI VTRFRRFLSV
     VFGKENLAAN IAYIEQVLGK SIRKYFVNDF YNDHVKMYSN RPIYWQYSSQ TNNKGSFKAL
     VYLHRYTPKT TNVVLNYLRD YTGKIADIAD GLERSDRTAD KKQAAKLRKV VLECKDYEDQ
     TLYPLATRNL EIDLDDGVLV NYLRMGKALR SIPAIEKKRK EVSTWTWPVH PLGKE
//