ID E4WV56_OIKDI Unreviewed; 766 AA.
AC E4WV56;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSOID_T00009513001 {ECO:0000313|EMBL:CBY21738.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY21738.1};
RN [1] {ECO:0000313|EMBL:CBY21738.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 7 family.
CC {ECO:0000256|ARBA:ARBA00005735}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; FN653017; CBY21738.1; -; Genomic_DNA.
DR AlphaFoldDB; E4WV56; -.
DR InParanoid; E4WV56; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd00041; CUB; 1.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR003859; Galactosyl_T.
DR InterPro; IPR027791; Galactosyl_T_C.
DR InterPro; IPR027995; Galactosyl_T_N.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR19300; BETA-1,4-GALACTOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19300:SF62; BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR Pfam; PF02709; Glyco_transf_7C; 1.
DR Pfam; PF13733; Glyco_transf_7N; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR02050; B14GALTRFASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 254..427
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 615..754
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
SQ SEQUENCE 766 AA; 85377 MW; 4F1439E8C0F52737 CRC64;
MNVGFDIAKK DGFQCFFFHD VDLVPENDKN IYECLDVPRH YAAHCDKWNY TLPWFTLYGG
ITAYSLEAYE NINGLSNEYW GWGGEDDDQM YRTTTGCGYQ ILRPPEEFNR YKMIKHEHEK
SNAKNPLNLE LLWSWAWHWA IDGIVQHHHV QQIWSIDEAQ FNTTKTVALK SSVSGKFNVD
WDKLEYDELT IPTYSMLALF LYLEHLNEFP IPYSIDAQAA IYESITHHNV DGFKDGVDEL
DQITQDQCRT NALDIVFVVD ESGSIGTPNF QLIKDFLEHF ASDSTIAADA TRIAIRPFST
SNYLYFSLND FKTKNIINEI KNMPYNSGNT NTADALDAAL TDYGTDRPES VKVMVTITDG
ASNSFLSTSA AADRVKNDLR NIQSFAIGVS GANMAELEAI AITDKHVFML NGWADFEPIK
SNLLQKVCEG NIENNNGGDT QVGGNAGTPG KIILKIGMTG KDNFDFMGSA PLTFFYHRSN
PQPGPAVYEH SVNVTSASAN IWHNYNVGPG YTFVYLSAYN YNPSNALVSL RINSGGSSGP
IVPDPVLCPP NSHCVGGTCE CFPQYSLDAN TGDCVFDRCA NVDCFNGYQC APATGSCFCP
ADHLELDGNC YEAVCPDSAV QVHENVFGYA MGELSSPWRE HGMLYPNNFD CTYEFETVRA
NGSCYEVLLE DYFGVEASAN CQSDRLEIHD VMNADQVNMD HSTSRPAGAA IMCGDACVAE
GGWVGKVCGD KLKIRFKSDH IVEDIGWRLK WVLRPKEECD CLCNRP
//
