ID E4WYV1_OIKDI Unreviewed; 618 AA.
AC E4WYV1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Calpain catalytic domain-containing protein {ECO:0000259|PROSITE:PS50203};
GN ORFNames=GSOID_T00013643001 {ECO:0000313|EMBL:CBY22867.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY22867.1};
RN [1] {ECO:0000313|EMBL:CBY22867.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; FN653019; CBY22867.1; -; Genomic_DNA.
DR AlphaFoldDB; E4WYV1; -.
DR MEROPS; C02.029; -.
DR InParanoid; E4WYV1; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 46..360
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 112
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 278
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 298
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 618 AA; 70263 MW; F0998A9FCBAE7E7C CRC64;
MYSTRGNHQE PSSSLAAARS DSSKLSSEEI AVLRRSSFIN GKKFVPFFPG DASYANLSGN
GRWRDSDGIL DLSAKQQKRL AGWAPAEDYI PNATVVNQVS PRNVTQTLVS DCSFVSAMIL
SAGYENKFHT QIITNSLFPQ NRERKPVLNP YGKYCVRLHI NGCWRLVEVD TRFPFDQNGR
LLTSYSKDKA ELWVSLLEKA YLKVMGGYDF PGSNSSIDLH ALTGWIPERK ALQDTGNDDG
RFFTMLKTRM GSGHVLATMA SGRLSSDLEE KSGLVPTHAY ALLDLRQVGN LRFVKLKNPW
AERSWKGKYS YQDSTRWTSE LQRMLSYDPK AAAADDQGVF WIEWNDLIIY FDVCYLSWNT
SLFKFDRKFH GSWPQGPKKD LYSFANNPQY LLTIDSSVDT MVWLLLSRHI TEKDDFAENK
DFITLIVYKN NGERLYLPTS GTKVLDGIRI NSPFYLAKLP VSKSSSHEKY TIIVSEYEKN
HDIDFTLTAY ANVKFSLKEL NDNFSHQKRV KSEWNSSNAG GCQNNRETYS SNPITKITIC
SKCTLLIEIR APKQYSVQMQ LEDLSEKKLE ESGSYRSGYS VLKTVLDPGT YQIRSSTFNK
GEIGPFFLDF SSDMQFLL
//
