ID E4X8V5_OIKDI Unreviewed; 959 AA.
AC E4X8V5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=SMP-30/Gluconolactonase/LRE-like region domain-containing protein {ECO:0000259|Pfam:PF08450};
GN ORFNames=GSOID_T00004588001 {ECO:0000313|EMBL:CBY19165.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY19165.1};
RN [1] {ECO:0000313|EMBL:CBY19165.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SIMILARITY: Belongs to the gamma-glutamyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009381}.
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DR EMBL; FN653030; CBY19165.1; -; Genomic_DNA.
DR AlphaFoldDB; E4X8V5; -.
DR InParanoid; E4X8V5; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0036374; F:glutathione hydrolase activity; IEA:InterPro.
DR GO; GO:0006751; P:glutathione catabolic process; IEA:InterPro.
DR Gene3D; 1.10.246.130; -; 1.
DR Gene3D; 3.60.20.40; -; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR043138; GGT_lsub_C.
DR InterPro; IPR000101; GGT_peptidase.
DR InterPro; IPR043137; GGT_ssub.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR013658; SGL.
DR PANTHER; PTHR11686:SF72; -; 1.
DR PANTHER; PTHR11686; GAMMA GLUTAMYL TRANSPEPTIDASE; 1.
DR Pfam; PF01019; G_glu_transpept; 1.
DR Pfam; PF08450; SGL; 1.
DR PRINTS; PR01210; GGTRANSPTASE.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..959
FT /note="SMP-30/Gluconolactonase/LRE-like region domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003192738"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..325
FT /note="SMP-30/Gluconolactonase/LRE-like region"
FT /evidence="ECO:0000259|Pfam:PF08450"
FT REGION 935..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 770
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR600101-1"
SQ SEQUENCE 959 AA; 105798 MW; 42AE288FF029177F CRC64;
MRMFRCLSLF VSCLTATEIN MTPGGMPSPP TKQIVADKRY EGLVGKGEWE MILNVMVWSE
GPTWGCMSEL FNILPPTWWQ NKLVFSDTRL EKIYSWDPKS KLTDVVMEKA GYGIDPVIDT
HLWMEPGSNG LAANPHTGEL VICQHGSRAL AALSPDGNLR KLVTKTSFGP LNSPNDVAIH
KTTGDIFFTD PVFGKQTVNN NLIRGNMGGA PELDTPGFSG VYRYNPKNEK VTLVNNEMQQ
PNGIGITPDN ELIVAYCNET VWQWWKWQLN EDGSVAGEKT IFIDGKDTMS GPGYPDGLHV
DEEGNVWVSG PGGLYIYDKN GVFLGGEKFT TIATSNVLVA PEGAVKLSNG SCLAVLKMGL
QRKWIYAAVF LVCALGLGLG LGFGLSGKEE LEDPVFEFPA DKPCIEDPNT GCYREQAAAT
DDSRCSIIAN DIMNKGGSAV DSAIAAIACE GVVNGYHSGI GGASFMTVYD EKTKKAEFFN
CRERAPLAST EDMFKDKPNE AMHGPLAIAV PGEVKCMKEA HARYGSLPWS DIFQPSVDLA
RNGWELWNYT YLAMEDKADF LQGDYISWAG KNWTGNWEPY LKDNGKIKII GDKIKDEELA
KTLEMIQQDP DSFYNGLLAD LIIEDLKELN ATITKEDLQN YKALVSSPLE STYGDLKFFF
PRAPSSGPIL QLMMNIIEGY KLSPESRVDP LANHRIVESM KHGYAIRTGL GDPEFYPYDQ
ADLEKKITGF YGAVDRFLKI KQALPDFEPS QTHDIDYYNP IFQGKDDHGT LSVSTQDKNG
QAVAVTTTVN LYFGSKLRGR RTGITFNDGM DDFSTTGFNN DFGVPPSPMN FVKGGKRCVS
SMAPTIAIDK NSGKAKIVIG AAGGTKITTG IYQVLLNKIW LGYSGSDSVR RHRFHHQLDP
NEINWSDAVD GIDGPEWEEM IRALERDHGH KLRETGRINS DNTIEGVSDW RHGGVPDGK
//
