ID E4XES2_OIKDI Unreviewed; 225 AA.
AC E4XES2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Osteoclast-stimulating factor 1 {ECO:0000256|ARBA:ARBA00040640};
GN ORFNames=GSOID_T00008716001 {ECO:0000313|EMBL:CBY19569.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY19569.1};
RN [1] {ECO:0000313|EMBL:CBY19569.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC cascade which results in the secretion of factor(s) enhancing
CC osteoclast formation and activity. {ECO:0000256|ARBA:ARBA00037432}.
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DR EMBL; FN653042; CBY19569.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XES2; -.
DR InParanoid; E4XES2; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR CDD; cd11772; SH3_OSTF1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24155; OSTEOCLAST-STIMULATING FACTOR 1; 1.
DR PANTHER; PTHR24155:SF10; OSTEOCLAST-STIMULATING FACTOR 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 13..72
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REPEAT 114..147
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 148..180
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 225 AA; 24476 MW; 418E27723F0F8481 CRC64;
MSRAKPALAR KPSTVKCFRA HWGYEGAADD ELSFEEGDLV YISEQHDGGW WRGTCKGRSG
LVPSNYLVAD EDEENSGSNG QIDFPLHEGA KRGNLEWVDE CLENTVPING QDRSGSTGLY
WAAYGGHVEV VERLLQNKFT DLNLQNKLGD SPLIGAAIRS HPEVVDLLLK AGADPSITNN
TDGSALSVAT NNQVKSLIKA RLGLKTERKN QSDYIGAESD NESDA
//
