ID   E4XR44_OIKDI            Unreviewed;       268 AA.
AC   E4XR44;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=phosphoethanolamine N-methyltransferase {ECO:0000256|ARBA:ARBA00035674};
DE            EC=2.1.1.103 {ECO:0000256|ARBA:ARBA00035674};
GN   ORFNames=GSOID_T00018159001 {ECO:0000313|EMBL:CBY12280.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY12280.1};
RN   [1] {ECO:0000313|EMBL:CBY12280.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine =
CC         H(+) + phosphocholine + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:25325, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:58641, ChEBI:CHEBI:59789, ChEBI:CHEBI:295975;
CC         EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00035588};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25326;
CC         Evidence={ECO:0000256|ARBA:ARBA00035588};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-methylethanolamine phosphate + S-adenosyl-L-methionine =
CC         H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:25321, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57781, ChEBI:CHEBI:57856, ChEBI:CHEBI:58641,
CC         ChEBI:CHEBI:59789; EC=2.1.1.103;
CC         Evidence={ECO:0000256|ARBA:ARBA00035580};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25322;
CC         Evidence={ECO:0000256|ARBA:ARBA00035580};
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004969}.
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DR   EMBL; FN653112; CBY12280.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4XR44; -.
DR   InParanoid; E4XR44; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR44307; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR44307:SF2; PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1; 1.
DR   Pfam; PF13847; Methyltransf_31; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          56..172
FT                   /note="Methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF13847"
SQ   SEQUENCE   268 AA;  30498 MW;  D1CDEECEA065DE5C CRC64;
     MSEQQSYDSA EFQKFLDEQQ YSRNRILRYE KIFGVDFVST GGISTTREFV KMLKLKKGQK
     VLDVGCGIGG SAFHMNIEYG AHVEGFDLSR NMIDIANERA QKYNLKDVSF SVEDATLVEF
     PEATFDVIYS RDTILHIADK LALFKQFCKW LKPGGTLMIS DYCCTPNKWS KNYSAYVAQR
     GYNLLSVKDY GKTIGQAGFV DVQDIDYTSG FIEILKGELE LFATTKEDFI NEFSEKDYDA
     INGGWSDKVE RCTGGDQKWG LFIARKRA
//