ID   E4YDJ9_OIKDI            Unreviewed;      1045 AA.
AC   E4YDJ9;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Agrin {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GSOID_T00021534001 {ECO:0000313|EMBL:CBY33610.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY33610.1};
RN   [1] {ECO:0000313|EMBL:CBY33610.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; FN654430; CBY33610.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4YDJ9; -.
DR   Proteomes; UP000011014; Unassembled WGS sequence.
DR   CDD; cd00055; EGF_Lam; 2.
DR   CDD; cd00104; KAZAL_FS; 4.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 3.30.60.30; -; 4.
DR   Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR002049; LE_dom.
DR   PANTHER; PTHR10913:SF45; AGRIN; 1.
DR   PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR   Pfam; PF07648; Kazal_2; 5.
DR   Pfam; PF00053; Laminin_EGF; 2.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   SMART; SM00180; EGF_Lam; 2.
DR   SMART; SM00280; KAZAL; 5.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 4.
DR   PROSITE; PS01248; EGF_LAM_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 4.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   4: Predicted;
KW   Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292}.
FT   DOMAIN          55..104
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          238..291
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          315..362
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          386..434
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          821..999
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
SQ   SEQUENCE   1045 AA;  116862 MW;  A30F1B11A428BED9 CRC64;
     MHAPAFCIYE KSNQIIAACE PVVKAFIECE FVEDKCARTS CSFGAVCDPT SGKCECVDMR
     CERKEVTAVC GSDGITYLNE CELEHAQCRE QQLVSLQYHG LCRDVQVAEI ECRRDNECQN
     GSICNVGICR CPACDDDAPA DENINELAVE HGGICRVCNP IYWDGVATRN SRYCEGSCLE
     CENEPFSTIV CATKGSFRRV FASECLAKCS MGDDVDLTVG GCYEPPCEEC RDKECKLFGT
     EWKCNCPLCP AENNPVCGSD GVTYNSLCVM KRTNCEFGSG IELVSSGKCP EKGEEEDKTC
     EGCFFGAYCE RGRCKCDYNC KSIDRPVCGD NNIDFKNECF LREFECQIQQ PFDIVKSGHC
     SVENDQKNCP IYTAGVERTV DGVECHCPEC DHHFGDSAVC GSDGKLYDSR CELRSQACHF
     NEQIFEVPLD HCGLEIEGSG GGEVCKFGGV DASDRFDDDE EFSRQIYCRC NWHCEDDGAQ
     VVAEGVVFDN LCKYYRDGNC KNQRELVITK SNCHCNNPGA YDREGPCDHA EGCLCKPGYK
     GKHCEDCELN YYQLNGRCMQ CSCSQQGSRG ALCDENGQCF CKAGFIGQKC DIKVEQDRDQ
     CQACSSPEIE SGAICGDDHR IYGSRCAMRR LHCNKKPENQ PEAVKYFKQC LFSGYPQIEI
     DEDESSEESE IMEDIIMLPV LPPTQKPTDE PEGSGGYVDP QFSTCDDEEC GDNSISLSEA
     KLPQDSSIDF DSIRYDVVLT LKNNMDWNDK ERIEKDLSAV FASELSEINL KSAVIDKIED
     KSAILSIEIS PDKPYLEAKI NSHLQENIDR SSFSQFNIVH GQWFGGESFE RYSFEKCDTT
     YEFEIKFKFR TRDPNGVIFW AGSPDTLDKR LALTIKDSKL ELSFAKNEPF RYKKAVDDNV
     WHTVELKFNR GGITLILDHI PRPEYIATGK KDSRELDLSN IYIGGIPKDQ ELDILSSLEI
     NKGLTGCFQM IGGSAMKSGV SENKDYPIKS VYSYGIAKCD GRSPCQNNLN ECDKDDSCVE
     WDSLRFCEAS KGPHRLQGVK MNGSR
//