ID E5C4E5_9BACE Unreviewed; 1624 AA.
AC E5C4E5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BSGG_1031 {ECO:0000313|EMBL:EFS30331.1};
OS Bacteroides sp. D2.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=556259 {ECO:0000313|EMBL:EFS30331.1, ECO:0000313|Proteomes:UP000003135};
RN [1] {ECO:0000313|EMBL:EFS30331.1, ECO:0000313|Proteomes:UP000003135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D2 {ECO:0000313|EMBL:EFS30331.1,
RC ECO:0000313|Proteomes:UP000003135};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Allen-Vercoe E., Strauss J.,
RA Sibley C., White A., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides sp. D2.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFS30331.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACGA02000062; EFS30331.1; -; Genomic_DNA.
DR RefSeq; WP_009000715.1; NZ_JH636026.1.
DR HOGENOM; CLU_002862_0_0_10; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000003135; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 297..477
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 507..654
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1072..1579
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 1093..1100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1624 AA; 186135 MW; 21971C0381519ACF CRC64;
MSIWSKLIGI KKTEDRNNAI GNKITSVPFS APNYAIVDVE VGLKDHKIHD IGALLHDGTT
FHKTSKDELF SFLCDIDYIC GHNIIHHDAK YLFTDKTCRW ILVDTLYVSP LLFPERPYHR
LVKDDKLISE QMNNPVNDCK KANDLLLDEI ACWNSLPKEK RILFASLLKG KKEFEGFLRI
MNAEYINEGI PELIKKLYAG KICQHADLDM LIEQYPCGLA YALALIDTTD YRSITPGWVL
YNYPEVEFIV KLLRHTSCRE GCDYCNTQLD VLHNLKVFFG YERFRTYEGE PLQEQAAQAA
VKGKSLLAIF PTGGGKSLTF QLPALMAGRS VHGLTVVISP LQSLMKDQVD NLADRGITDA
VTINGMLDPI TRALSIQRVQ DGEASLLYIS PEMLRSKTIE KILIARHVVR FVIDEAHCFS
SWGQDFRVDY LYIGKFIREY QQKKKCKNPI PVSCFTATAK QKVVQDICDY FKQTLNLDLE
LFASTASRTN LRYSVIHADS DNDKYLKLRE LVAESNCPTI IYVSRTKRTE ELATKLTRDG
YKALPFNGKM ESDEKIANQD AFMNDQVHII VATSAFGMGV DKKDVGLVVH YDISDSLENY
VQEAGRAGRD PSLSARCYVL YSDNDLDKHF ILLNQTKLSI SEIQQVWKAI KDLTRQRMKV
SCSALEIARQ AGWDDSVSDI ETRVRTALAA LEQSGYLIRG NNVPHVYATG ITVKNMDEAR
KRISMSLLFD RDEIEKAVRI IKSLISQKHI AKAQDSEAES RIDYLADILG ISKREVISVV
ERMRQEGILA DSKDISAYLL DAGDSERKSQ TLLERFAKLE QYILNHIPDE SLRISCKQLN
DNAVNNGINT SKEKDIRTLL YFLTVKGYTR KKEDAVRNIE ISRQADLEST IKRFEKRLEI
SRFAIEWLYR IASDTETGNS PNKAIQFSVV ELLNQIKSSP QSLFGGLDDI QLEDVEEALL
YLSKIGALKL EGGFLVLYNA MNIQRIKDNK SRYKQDDYRM LNEFYKQKIQ QVHIVGEYAN
LMVRDYNTAL RYVQDYFQMD YRKFVTKYFK GDRVSEIQRN LTPQKYKQLF GQLSKRQMEI
ISDKDSRCIV VAAGPGSGKT RVLVHKLASL LLLEDVKHEQ LLMLTFSRAA ATEFKQRLME
LIGNAAHFIE IKTFHSYCFD LLGRIGNLED AKSVVAKAAE MICQGEVEPN KIGKTVLVID
EAQDMGVEEY ALLRALMANN EEMRVIAVGD DDQNIYEFRG SDSDYMYRLT QENGSKFVEM
TENYRSAHHP VNFANGFLRT IDKRIKSTPI ISMRKEEGWV EVTRHQSKYM YQPLVEKLLQ
HKDKGTSCVL TQTNEEAVIL MALLRKHGIN SKLIQSMDGL RFWNMAEIRY LLRYIDKRAK
TPLIPEELWE EAKHATFSAY DGSLSLTYVK RCVEQFEQTN KAKYLCDFKE FVFESSVEDF
CDVSGAEVVV STIHKAKGRE FDDVYILVSD NYSKDAYLMR KYYVGITRAK NRLFIHTNGD
CFNRLSTDRY FVDQRQYDMP EEIVLQLSHK DVYLGFFKER KQEVLALRGG DSLNYNDFFL
YSSSTNKPVA RLSLKMQDTL SEWEERGYKV KSASVRFVVA WKPKDAQKNE SETAVLLADL
VLSL
//
