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Database: UniProt
Entry: E5CYR8_CHLTH
LinkDB: E5CYR8_CHLTH
Original site: E5CYR8_CHLTH 
ID   E5CYR8_CHLTH            Unreviewed;      1029 AA.
AC   E5CYR8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Penicillin binding protein {ECO:0000313|EMBL:ADJ67948.1};
DE   Flags: Fragment;
GN   Name=pbpB {ECO:0000313|EMBL:ADJ67948.1};
OS   Chlamydia trachomatis.
OC   Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=813 {ECO:0000313|EMBL:ADJ67948.1};
RN   [1] {ECO:0000313|EMBL:ADJ67948.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PbpB_26 {ECO:0000313|EMBL:ADJ67948.1};
RX   PubMed=17329456; DOI=10.1128/JCM.02301-06;
RA   Klint M., Fuxelius H.H., Goldkuhl R.R., Skarin H., Rutemark C.,
RA   Andersson S.G., Persson K., Herrmann B.;
RT   "High-resolution genotyping of Chlamydia trachomatis strains by multilocus
RT   sequence analysis.";
RL   J. Clin. Microbiol. 45:1410-1414(2007).
RN   [2] {ECO:0000313|EMBL:ADJ67948.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PbpB_26 {ECO:0000313|EMBL:ADJ67948.1};
RA   Herrmann B., Klint M., Christerson L.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; GQ352778; ADJ67948.1; -; Genomic_DNA.
DR   AlphaFoldDB; E5CYR8; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 2.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 2.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT   DOMAIN          24..252
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          312..340
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   DOMAIN          798..1016
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADJ67948.1"
FT   NON_TER         1029
FT                   /evidence="ECO:0000313|EMBL:ADJ67948.1"
SQ   SEQUENCE   1029 AA;  117979 MW;  6EEDEF6AC64A8F22 CRC64;
     VQHEKKKEEA YRPQLRSIPE HCDRAGVCDR FGKTLAENVL QYNVGISYRA IRDIPTRVWH
     TDEKGNKKLV PVRKDYIKKF ADFLAQELHM DRDFVEDTIH AKASVLGSVP YILQANVSER
     TFLRLKMLEK DWPGLHVESS VRRHYPEGRT LADLLGYVGP ISAEEHRKIT RELGNLRECI
     RAYEEGEDPK FPAGISSIDQ VRKLLHELEM HAYGLNSLIG KLGVEAFCDR KLRGLIGKRS
     MLVDRRGNFI QEMEGSSVGS PGRKIQLTIS TELQAFAHEL LAEHERGEVF CDYRQWRQQQ
     YLPPFFPWIK GGAIVAMDPK NGQILAMASS PRYDNNDFIN MKDSPNQEEC RSSVLRWLEN
     LEYIGEVFDR RVPLRRERLD PLSGKYFDEE LSFSYRAFLD FILPDTSKVK QMLCEKGSVG
     LSIYLQGTIE QLLEMFECEE KECGLVFDVL FPKENGHEII GEITSLKRQK QFKAILAERE
     EEVQAFRERL GSIFADLSAN YDKILFLDLL RTAVDPEKIS ISLLAEIGHM SVLDFVNYQG
     HFIALRKSFA KLMENAFIDH DFTAWREEHF TQFIKQKRDE ELERKQQYPT PYVDYLVEER
     SRQYALFCRE HMDSFITFLL SEIEPPLGNP YYQEIACWRQ ELRSGAYPAL EWREHYDFLH
     KHLSQTSYDL CELFAAFREF SELKRPLYGQ YPLTLTRNIE QIEQDLIASF YPLYGYGHLS
     AHAFGQAATL GSIFKLVSAY SVLVQHLSDQ EDLSKLLVIV DKQSLGLRSG KPHVGFFKDG
     SPIASFFKGG ILPGNDYSGR GYIDLIAALE MSSNPYFSLL VSEYLSDPED LCEAAKLFGF
     GEKTGIGLPG EYAGRVPIDV AYNRSGLYAT AIGQHTLVVT PLQTAVMMAT LVNGGIVYQP
     SLIQGEWYQG SFSPEQAKKK REIFLPDSIV DLFKRGMHNV IWGQYGTTRF MRQRFAPERL
     ARIIGKTSTA EVIARVGLDR ERGRMKLKDV WFAAVGYEDE ALSHPDIVVV VYLRLGEFGR
     DAAPMAVRI
//
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