ID E5D4R2_9SAUR Unreviewed; 170 AA.
AC E5D4R2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:ADP24572.1};
OS Gonatodes seigliei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Sphaerodactylidae; Gonatodes.
OX NCBI_TaxID=911503 {ECO:0000313|EMBL:ADP24572.1};
RN [1] {ECO:0000313|EMBL:ADP24572.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=27G {ECO:0000313|EMBL:ADP24572.1};
RA Schargel W.E., Rivas G., Makowsky R., Senaris J.C., Natera M.A.,
RA Barros T.R., Molina C.R., Barrio-Amoros C.L.;
RT "Phylogenetic systematics of the genus Gonatodes (Squamata:
RT Sphaerodactylidae) in the Guayana region, with a description of a new
RT species from Venezuela.";
RL Syst. Biodivers. 8:321-339(2010).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU139890; ADP24572.1; -; Genomic_DNA.
DR AlphaFoldDB; E5D4R2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 130..170
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADP24572.1"
FT NON_TER 170
FT /evidence="ECO:0000313|EMBL:ADP24572.1"
SQ SEQUENCE 170 AA; 19056 MW; 2F4DBBDF1CB9A7B9 CRC64;
IQSTNMDQRS LPEDSINSLI IKLIQADILK SKVSKQVVDI KDSTADTVKK AEAVEPDVDS
TENVKLDFQP VISMDTELLK QQRRYSSPRV LLSDNTPLEP PPLYLMEDYI GNSVVGNRTS
RRKRFAESKS HRGEYSVCDS ESRWVTDKSS AIDIKGNQVT VLGEIRMGPS
//