ID E5FNJ3_TREPL Unreviewed; 814 AA.
AC E5FNJ3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit {ECO:0000313|EMBL:QFP69430.1};
DE SubName: Full=ClpA {ECO:0000313|EMBL:ADR64244.1};
DE EC=3.4.21.92 {ECO:0000313|EMBL:ADR64244.1};
GN Name=clpA {ECO:0000313|EMBL:ADR64244.1};
GN ORFNames=FA889_02845 {ECO:0000313|EMBL:QFP69430.1};
OS Treponema pallidum.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=160 {ECO:0000313|EMBL:ADR64244.1};
RN [1] {ECO:0000313|EMBL:ADR64244.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fribourg-Blanc {ECO:0000313|EMBL:ADR64244.1};
RX PubMed=21209953; DOI=10.1371/journal.pone.0015713;
RA Mikalova L., Strouhal M., Cejkova D., Zobanikova M., Pospisilova P.,
RA Norris S.J., Sodergren E., Weinstock G.M., Smajs D.;
RT "Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue
RT strains: most of the genetic differences are localized in six regions.";
RL PLoS ONE 5:E15713-E15713(2010).
RN [2] {ECO:0000313|EMBL:QFP69430.1, ECO:0000313|Proteomes:UP000325938}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UW-148B {ECO:0000313|EMBL:QFP69430.1,
RC ECO:0000313|Proteomes:UP000325938};
RA Addetia A., Greninger A.;
RT "Genomics of syphilis reinfection.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HM585227; ADR64244.1; -; Genomic_DNA.
DR EMBL; CP045005; QFP69430.1; -; Genomic_DNA.
DR RefSeq; WP_010881996.1; NZ_LT990038.1.
DR AlphaFoldDB; E5FNJ3; -.
DR OMA; GRVIQEH; -.
DR Proteomes; UP000325938; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:QFP69430.1};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000313|EMBL:ADR64244.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:QFP69430.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 2..149
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
SQ SEQUENCE 814 AA; 91582 MW; 997545B16F9ACFD4 CRC64;
MLQDLSANAR KVLLELGQTV AREARASLLQ PEHILLALIQ HKVGRGYKLI EKLIEDVATV
RLILEQHVLT NEGDVASPQD LPVSGRVKHL LDIAAMEARS LRCAYIGTEH LVIAFAREEQ
NPLFQSLIRE GLSLDDLRNA SIISSPHSDT TRTRLERKVA SVLDEYGTDL TERARAGALN
PVIGRNKEIT RVIQILCRRG KNNPVLIGEP GVGKTSIVEG LAYAIVREEV PHILLHTRVV
SLDLAAVIAG TKYRGQFEER LKRIIKEVEE TEKVILFIDE LHTLIGAGGT QGSLDAANML
KPALARGQIQ CIGATTLAEY RRYFEKDAAL TRRFRSVLVR EPSFEETCTI LRKIKSHYER
HHQVIYQSDA LEKIVELSRR YIPERFFPDK AIDLMDEVGA MKRVQQRADT QVLRSFSIKV
ANLTTETERA IALEDWARAR SLHTDVVQLR RRLHALKVEW SAREALSIFA EDVAQAVSLM
TDIPVHSLEG DELCRFTNIE RDLCATVRGQ REAIATLARA IVRARVGISS DTRPIGSFLF
LGPTGVGKTL LAKTLAEFLF GSADALIRID MSDYMERYNT SRLMGAPPGY VGFENGGLLT
ERVRHRPFSV ILLDEIEKAH PDVFNVLLQV LEEGELQDNL GHTVNFRNTI IIMTSNAGTR
GLGENVPGFQ TARARNIEYR QLRVQALREI KRIFSPEFLN RVDECVVFAP LERETLQEIL
ECELKKLAER LRGKDIVLRY SAAAKAYCLE HGFDPFLGAR PLRRVLQQEI ENELALRMIH
GTLRAGSCVH IDSDGARLHL STEKSYLTLH PQEI
//