ID E5KQS5_HUMAN Unreviewed; 342 AA.
AC E5KQS5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=HCG2044837 {ECO:0000313|EMBL:EAW74334.1};
DE SubName: Full=Sorting nexin-15 {ECO:0000313|EMBL:ADP91254.1};
GN ORFNames=hCG_2044837 {ECO:0000313|EMBL:EAW74334.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADP91254.1};
RN [1] {ECO:0000313|EMBL:EAW74334.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2] {ECO:0000313|EMBL:EAW74334.1}
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ADP91254.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20843780; DOI=10.1093/nar/gkq750;
RA Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R.,
RA Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M.,
RA Speed T.P., Scharfe C.;
RT "Identification of rare DNA variants in mitochondrial disorders with
RT improved array-based sequencing.";
RL Nucleic Acids Res. 39:44-58(2011).
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DR EMBL; HQ205586; ADP91254.1; -; Genomic_DNA.
DR EMBL; HQ205587; ADP91256.1; -; Genomic_DNA.
DR EMBL; HQ205588; ADP91258.1; -; Genomic_DNA.
DR EMBL; HQ205589; ADP91260.1; -; Genomic_DNA.
DR EMBL; HQ205590; ADP91262.1; -; Genomic_DNA.
DR EMBL; HQ205591; ADP91264.1; -; Genomic_DNA.
DR EMBL; HQ205592; ADP91266.1; -; Genomic_DNA.
DR EMBL; HQ205593; ADP91268.1; -; Genomic_DNA.
DR EMBL; HQ205594; ADP91270.1; -; Genomic_DNA.
DR EMBL; HQ205595; ADP91272.1; -; Genomic_DNA.
DR EMBL; HQ205596; ADP91274.1; -; Genomic_DNA.
DR EMBL; HQ205597; ADP91276.1; -; Genomic_DNA.
DR EMBL; HQ205598; ADP91278.1; -; Genomic_DNA.
DR EMBL; HQ205599; ADP91280.1; -; Genomic_DNA.
DR EMBL; HQ205600; ADP91282.1; -; Genomic_DNA.
DR EMBL; HQ205601; ADP91284.1; -; Genomic_DNA.
DR EMBL; HQ205602; ADP91286.1; -; Genomic_DNA.
DR EMBL; HQ205603; ADP91288.1; -; Genomic_DNA.
DR EMBL; HQ205604; ADP91290.1; -; Genomic_DNA.
DR EMBL; HQ205605; ADP91292.1; -; Genomic_DNA.
DR EMBL; HQ205606; ADP91294.1; -; Genomic_DNA.
DR EMBL; HQ205607; ADP91296.1; -; Genomic_DNA.
DR EMBL; HQ205608; ADP91298.1; -; Genomic_DNA.
DR EMBL; HQ205609; ADP91300.1; -; Genomic_DNA.
DR EMBL; HQ205610; ADP91302.1; -; Genomic_DNA.
DR EMBL; HQ205611; ADP91304.1; -; Genomic_DNA.
DR EMBL; HQ205612; ADP91306.1; -; Genomic_DNA.
DR EMBL; HQ205613; ADP91308.1; -; Genomic_DNA.
DR EMBL; HQ205614; ADP91310.1; -; Genomic_DNA.
DR EMBL; HQ205615; ADP91312.1; -; Genomic_DNA.
DR EMBL; HQ205616; ADP91314.1; -; Genomic_DNA.
DR EMBL; HQ205617; ADP91316.1; -; Genomic_DNA.
DR EMBL; HQ205618; ADP91318.1; -; Genomic_DNA.
DR EMBL; HQ205619; ADP91320.1; -; Genomic_DNA.
DR EMBL; HQ205620; ADP91322.1; -; Genomic_DNA.
DR EMBL; HQ205621; ADP91324.1; -; Genomic_DNA.
DR EMBL; HQ205622; ADP91326.1; -; Genomic_DNA.
DR EMBL; HQ205623; ADP91328.1; -; Genomic_DNA.
DR EMBL; HQ205624; ADP91330.1; -; Genomic_DNA.
DR EMBL; HQ205625; ADP91332.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW74334.1; -; Genomic_DNA.
DR RefSeq; NP_037438.2; NM_013306.4.
DR AlphaFoldDB; E5KQS5; -.
DR SMR; E5KQS5; -.
DR Antibodypedia; 29586; 251 antibodies from 30 providers.
DR DNASU; 29907; -.
DR GeneID; 29907; -.
DR KEGG; hsa:29907; -.
DR CTD; 29907; -.
DR VEuPathDB; HostDB:ENSG00000110025; -.
DR OMA; YRFFTVT; -.
DR OrthoDB; 5476410at2759; -.
DR BioGRID-ORCS; 29907; 24 hits in 1159 CRISPR screens.
DR GenomeRNAi; 29907; -.
DR ExpressionAtlas; E5KQS5; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd02677; MIT_SNX15; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR15508:SF8; LD24550P; 1.
DR PANTHER; PTHR15508; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00745; MIT; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
FT DOMAIN 1..130
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 245..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 38291 MW; 33F64A79EAF6BBDC CRC64;
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG
DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK
EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS
PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE
SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP
//
