ID E5RHT3_HUMAN Unreviewed; 277 AA.
AC E5RHT3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=t-SNARE domain containing 1 {ECO:0000313|Ensembl:ENSP00000429679.1};
GN Name=TSNARE1 {ECO:0000313|Ensembl:ENSP00000429679.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429679.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000429679.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000429679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
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DR EMBL; AC103758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC129918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001278860.1; NM_001291931.1.
DR AlphaFoldDB; E5RHT3; -.
DR SMR; E5RHT3; -.
DR MassIVE; E5RHT3; -.
DR PeptideAtlas; E5RHT3; -.
DR ProteomicsDB; 16080; -.
DR Antibodypedia; 14519; 91 antibodies from 14 providers.
DR DNASU; 203062; -.
DR Ensembl; ENST00000519651.5; ENSP00000429679.1; ENSG00000171045.16.
DR GeneID; 203062; -.
DR UCSC; uc003ywl.5; human.
DR CTD; 203062; -.
DR HGNC; HGNC:26437; TSNARE1.
DR VEuPathDB; HostDB:ENSG00000171045; -.
DR GeneTree; ENSGT01000000214440; -.
DR HOGENOM; CLU_059257_1_2_1; -.
DR OrthoDB; 3682730at2759; -.
DR BioGRID-ORCS; 203062; 10 hits in 1156 CRISPR screens.
DR ChiTaRS; TSNARE1; human.
DR GenomeRNAi; 203062; -.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000171045; Expressed in skin of abdomen and 122 other cell types or tissues.
DR ExpressionAtlas; E5RHT3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF212; T-SNARE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF14523; Syntaxin_2; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Proteomics identification {ECO:0007829|EPD:E5RHT3,
KW ECO:0007829|PeptideAtlas:E5RHT3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 197..259
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 30150 MW; 6B050D468EF7747A CRC64;
MSYGSIARGG GLGSRGPFGG PSRQGCQPLA TQVDPCNLQE LFQEMSANVF RINSSVTSLE
RSLQSLGTPS DTQELRDSLH TAQQETNKTI AASASSVKQM AELLRSSCPE RLQQERPQLD
RLKTQLSDAI QCYGVVQKKI AEKSRALLPM AQRGSKQQSP QAPFAELADD EKVFNGSDNM
WQGQEQALLP DITEEDLEAI RLREEAILQM ESNLLDVNQI IKDLASMVSE QGEAVDSIEA
SLEAASSHAE AARQLLAGAS RHQLMRRTRP PAACGCP
//
