ID E5RIZ1_HUMAN Unreviewed; 136 AA.
AC E5RIZ1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Neurocalcin-delta {ECO:0000256|ARBA:ARBA00039391};
DE Flags: Fragment;
GN Name=NCALD {ECO:0000313|Ensembl:ENSP00000429255.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429255.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000429255.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000429255.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in the calcium-dependent regulation of
CC rhodopsin phosphorylation. Binds three calcium ions.
CC {ECO:0000256|ARBA:ARBA00037437}.
CC -!- SIMILARITY: Belongs to the recoverin family.
CC {ECO:0000256|ARBA:ARBA00006049}.
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DR EMBL; AP000426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E5RIZ1; -.
DR SMR; E5RIZ1; -.
DR MassIVE; E5RIZ1; -.
DR MaxQB; E5RIZ1; -.
DR PeptideAtlas; E5RIZ1; -.
DR ProteomicsDB; 16438; -.
DR Antibodypedia; 42836; 199 antibodies from 27 providers.
DR Ensembl; ENST00000520690.5; ENSP00000429255.1; ENSG00000104490.18.
DR UCSC; uc064pem.1; human.
DR HGNC; HGNC:7655; NCALD.
DR VEuPathDB; HostDB:ENSG00000104490; -.
DR GeneTree; ENSGT00940000158862; -.
DR OMA; MGCVCMK; -.
DR ChiTaRS; NCALD; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000104490; Expressed in Brodmann (1909) area 10 and 151 other cell types or tissues.
DR ExpressionAtlas; E5RIZ1; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028846; Recoverin.
DR PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1.
DR PANTHER; PTHR23055:SF87; NEUROCALCIN-DELTA; 1.
DR Pfam; PF00036; EF-hand_1; 2.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Proteomics identification {ECO:0007829|EPD:E5RIZ1,
KW ECO:0007829|MaxQB:E5RIZ1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 60..95
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 96..131
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT NON_TER 136
FT /evidence="ECO:0000313|Ensembl:ENSP00000429255.1"
SQ SEQUENCE 136 AA; 15749 MW; 27D43A0484D0CCA4 CRC64;
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD
ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE
MLEIVQAIYK MVSSVM
//
