ID E5WFK9_9BACI Unreviewed; 1035 AA.
AC E5WFK9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=HMPREF1013_01234 {ECO:0000313|EMBL:EFV78368.1};
OS Bacillus sp. 2_A_57_CT2.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=665959 {ECO:0000313|EMBL:EFV78368.1, ECO:0000313|Proteomes:UP000003283};
RN [1] {ECO:0000313|EMBL:EFV78368.1, ECO:0000313|Proteomes:UP000003283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2_A_57_CT2 {ECO:0000313|EMBL:EFV78368.1,
RC ECO:0000313|Proteomes:UP000003283};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Larson L., Lui A., MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacillus sp. strain 2_A_57_CT2.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV78368.1}.
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DR EMBL; ACWD01000020; EFV78368.1; -; Genomic_DNA.
DR RefSeq; WP_009331791.1; NZ_GL635751.1.
DR AlphaFoldDB; E5WFK9; -.
DR eggNOG; COG1511; Bacteria.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_0_0_9; -.
DR Proteomes; UP000003283; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003283};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 181..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..366
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 743..1031
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 1035 AA; 112443 MW; A8EA7C8C89B6344F CRC64;
MYSIIKRKWL VIVVWIAVVA GLFMAAPNMA DLVRDKGQIT VPEEYSSTLA GDIMQEVQKQ
EGGGDETQVA LVFHNDKKLT EEEIQEAEKA VRTLEEKSGE MGITEILTHF NEESLKDQLV
SEDGKSILTS VNVSWNDREP AELSEELYSA IDDAKVDHYY TSEWLINEDL MNSSQEGLKK
TEGITVVFIL VVLLLVFRSV VAPIIPLLTV GFTYLASQSI VAFLVDRLDF PISNYTQIFL
VAILFGIGTD YCILLLSRFK EELSYNESTA DAIVATYRNA GRTVFFSGLA VMIGFAAIGF
SQFILYQSAA AVAIGVAILL IALFTIVPFF MAVLGQKIFW PSKKSAEHGE SNLWGTVGRF
SLARPFVALL IVAAVCVPFL VTYDGELSYN SLEEIGGDVN SIKAFNAIAD SFGPGESMPT
QIVLKNDEEM DSAEYVGLAE KISREVEKVN LVDTVRSVTR PTGEPIEDFF VAKQAETLEE
GLGEGKDGLN KISDGLNEAS SELSKSEPEL QNATKGINDL ISGTNEIKSG LGEIQTNLAK
IEDGIRQGSV GSDQIKSGLG DAKAGAEELT ANYQKLLNGY QLSQQGLTQL QAGYSKASSG
LGEIMAANDA LYNHLDANYD QLAADQTYQT YKQAIQKNFG EVTGALYELN LRIAELNNGL
AEANKGFDVI LKEQSKLPAG LQQLVKGIEA QQAGLNQLAD GQGQIVDNFP KLTNGLAGIN
GGQEQLLAGF SGLGGQISQL TDGLGQSADG LEQVSEGLGS AQDYLAGLSN SENMDGFYLP
PEVLEDEEFA QVFDVYLSED RKVMTMDVVL EANPYSNEAI NQVGEIKEAV ERATKGTKLE
NAVVAVGGIT STNADLSTMS DQDYSRTVVL MLLGISIILV FLFRSIIMPI YLIGSLILTY
YTSMAMNEAI FVNLLGYSGI SWAVPFFAFV ILVALGVDYS IFLMDRFNEY RDLSIADAML
LSMKKMGTVI ISAAVILGGT FAAMMPSGML SLLQIASIVL VGLMLYALVM LPLFIPVMVK
NFGQANWWPF KRSAN
//
