ID E6JYT2_PARDN Unreviewed; 432 AA.
AC E6JYT2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:EFT83867.1};
DE EC=3.6.1.- {ECO:0000313|EMBL:EFT83867.1};
GN ORFNames=HMPREF0620_0872 {ECO:0000313|EMBL:EFT83867.1};
OS Parascardovia denticolens DSM 10105 = JCM 12538.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Parascardovia.
OX NCBI_TaxID=864564 {ECO:0000313|EMBL:EFT83867.1, ECO:0000313|Proteomes:UP000004946};
RN [1] {ECO:0000313|EMBL:EFT83867.1, ECO:0000313|Proteomes:UP000004946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10105 {ECO:0000313|EMBL:EFT83867.1,
RC ECO:0000313|Proteomes:UP000004946};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFT83867.1}.
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DR EMBL; AEON01000001; EFT83867.1; -; Genomic_DNA.
DR RefSeq; WP_006289260.1; NZ_CM001148.1.
DR AlphaFoldDB; E6JYT2; -.
DR KEGG; pdo:PSDT_0763; -.
DR PATRIC; fig|864564.6.peg.841; -.
DR eggNOG; COG0349; Bacteria.
DR HOGENOM; CLU_042387_3_0_11; -.
DR Proteomes; UP000004946; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR041605; Exo_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF18305; DNA_pol_A_exoN; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000313|EMBL:EFT83867.1};
KW Hydrolase {ECO:0000313|EMBL:EFT83867.1};
KW Nuclease {ECO:0000313|EMBL:EFT83867.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004946}.
FT DOMAIN 231..311
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 432 AA; 49790 MW; 82CBF8270D93CE7A CRC64;
MTYQEKHVRL LKEPAGGVPD LIDTRAEYDD FLQRFSSASG PIAVDAERAS GYRYSQQDWL
IQFKREGAGI ALIDPVALSE QEMDWQDVNE AFGDAVWIMH DSSQDLPGYF DLGLKPAGLF
DTERAARLLG QVRFGLAAVT ERYLDLTLAK EHSAADWSYR PLDRDMRIYA ALDVEVLIEL
EGLMKKDLKK AGKWDWAQED FIYLLNKGKQ AKPLKEEPWR GISHINVIDR DLRGLAIARA
LWTVRDRLAQ DNDIAPHLLL QDSAIIEAAQ RKPHNSQEFR RIRSLNQRVR VHKGDERDKM
FERYAPIQRK VKPQVWKEAI FQALSLPYDQ LPKRRNENPE TGENAPKSLK YWRIHHPDRY
ELLQSVRKFI TQVSEDTSTP TDIILKPKIV RNLCWHTDVD KTPAGIHAYL LKQGARAWQA
DLLSESLSSV IM
//
