ID E6KAL7_9BACT Unreviewed; 714 AA.
AC E6KAL7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Peptidase family M3 {ECO:0000313|EMBL:EFU29327.1};
DE EC=3.4.-.- {ECO:0000313|EMBL:EFU29327.1};
GN Name=dcp2 {ECO:0000313|EMBL:EFU29327.1};
GN ORFNames=HMPREF6485_2653 {ECO:0000313|EMBL:EFU29327.1};
OS Segatella buccae ATCC 33574.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=873513 {ECO:0000313|EMBL:EFU29327.1, ECO:0000313|Proteomes:UP000003112};
RN [1] {ECO:0000313|EMBL:EFU29327.1, ECO:0000313|Proteomes:UP000003112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33574 {ECO:0000313|EMBL:EFU29327.1,
RC ECO:0000313|Proteomes:UP000003112};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFU29327.1}.
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DR EMBL; AEPD01000049; EFU29327.1; -; Genomic_DNA.
DR RefSeq; WP_004346813.1; NZ_GL586311.1.
DR AlphaFoldDB; E6KAL7; -.
DR eggNOG; COG0339; Bacteria.
DR HOGENOM; CLU_001805_4_0_10; -.
DR Proteomes; UP000003112; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06456; M3A_DCP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR034005; M3A_DCP.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR43660; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR43660:SF1; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000003112};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..714
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003205273"
FT DOMAIN 261..712
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 714 AA; 80115 MW; D294CBFADF9BBA71 CRC64;
MNIKLGKALL AAALAAAMMP GTAATAQNKK GNLMENNPLM RPGTLPYGAP DFSKIKGEDY
LPALKEGIRQ QREEIARIVA DKAKPTFANT ILAYEKSGLL LDRVSSIFFA LVSADKTPEI
EQAEKEAVPL LTDFENEISF NQRFFQRIKY VYDHERNTLK GEDRKLLEEV YKKFVRSGAL
LPEDKMARMQ QINKRIAALQ QEFGNMLPKA TNAAAVWVES EGELAGLGAA DIAQCQKDAE
SRGGKAPYCI VITNTTQQPI LASLDNRALR ERVYRASIHR ADGSGDFNTF PIIAEMARLR
AEKARLMGFK DYASYSLDNA MAKNTDNTYR FLKQLIAAYT PKAQAETQAI EAYARRTMGP
DFKLEPYDRF YYSAKMKKEQ YSFSDDDVKP YFNIDSVLVN GVFYAAHRVY GLSFKQRTDL
PTYHADMKVF DVLDKDGHQL ALFYCDYFRR PTKRGGAWMS AFAKQSRLRR QLPIIYNVCN
YAKAPEGRPT LLTWDEVTTL FHEFGHALHG MLSDCRYNTL SGTAVARDFV EMPSQFNESF
ASIPEVFDHY ARHFETNLPM PETLKEKMLG SINFQPAYAL GENLAATCLD LAWHTLTAEQ
VPSADGAKDF ETSALREIGL LNSQIPPRYS TSYFNHVWGG GYAAGYYSYL WSEVLAVNIA
DYFAAHGALT PAVGQSFRDK VLSRGNTLDL MQMFSDFTGL PAPDATALLK ARGL
//
