ID E6KNC8_STROR Unreviewed; 1121 AA.
AC E6KNC8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Pilin isopeptide linkage domain protein {ECO:0000313|EMBL:EFU62495.1};
GN ORFNames=HMPREF8578_1743 {ECO:0000313|EMBL:EFU62495.1};
OS Streptococcus oralis ATCC 49296.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888049 {ECO:0000313|EMBL:EFU62495.1, ECO:0000313|Proteomes:UP000004500};
RN [1] {ECO:0000313|EMBL:EFU62495.1, ECO:0000313|Proteomes:UP000004500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49296 {ECO:0000313|EMBL:EFU62495.1,
RC ECO:0000313|Proteomes:UP000004500};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC {ECO:0000256|ARBA:ARBA00004168}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFU62495.1}.
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DR EMBL; AEPO01000015; EFU62495.1; -; Genomic_DNA.
DR RefSeq; WP_000791204.1; NZ_GL622183.1.
DR AlphaFoldDB; E6KNC8; -.
DR eggNOG; COG4932; Bacteria.
DR HOGENOM; CLU_002287_0_2_9; -.
DR Proteomes; UP000004500; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00222; CollagenBindB; 5.
DR Gene3D; 2.60.40.1280; -; 1.
DR Gene3D; 2.60.40.3050; -; 1.
DR Gene3D; 2.60.40.1140; Collagen-binding surface protein Cna, B-type domain; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR008454; Collagen-bd_Cna-like_B-typ_dom.
DR InterPro; IPR011252; Fibrogen-bd_dom1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR041033; Prealbumin-like.
DR InterPro; IPR041171; SDR_Ig.
DR InterPro; IPR022464; Strep_pil_isopept_link.
DR InterPro; IPR038174; Strep_pil_link_sf.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; TIGR03786; strep_pil_rpt; 1.
DR Pfam; PF17961; Big_8; 1.
DR Pfam; PF05738; Cna_B; 5.
DR Pfam; PF12892; FctA; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF17802; SpaA; 1.
DR SUPFAM; SSF49401; Bacterial adhesins; 2.
DR SUPFAM; SSF49478; Cna protein B-type domain; 5.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1121
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003205503"
FT DOMAIN 1088..1121
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 1061..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 123853 MW; 5921FEA97ECF3693 CRC64;
MKNKKFWLPI LTSLACLLGI IFAPNSVQAK ELKNVISNIG IWEVDNGKFI KPDANGVYTL
SPEHHNYSNY KFTVDYDLSA YDGKLEDGDT FTFTVPSPLT VRNETFDLKD KETDLVIGET
QIVSNGDNNG GKVTITLKNL KAYLEKKGGY QVQNVKGNFF VGFSSKNELS NETLRFDKTE
TINEITHQIK VKKGEASDYS EGIGRANFSK YHGLIYKEDW TSSALNKSGQ YLHSWYVRAN
PKQAAYNKIE IHDWVDPNAS PMQMIPETFK VTAGWYDKSY YFKDEVVLEA GKDYQVSWNE
SYTDFTLTIN NASSIVAKNG KPAAFRINYK TSAPADGTQV QNNAEMKGDD QILTYDDYSS
KTVVKQIGNS VVASGGTIQL ETGYRIILYK VDELTHDRLK GAKFKITPPA GATAKEEIVT
TNDDGIAESS IYSESDIKKG NFTVTEIEAP EGYELNPTPF EMTVGQDGAI KTVTNKRSKA
KVKIKANKKL TGRELKAEEF EFTLTDQDGK VKETVKNDKD GNIAFSELEF DKAGTYTFKI
AEKAGSDTSI KYDTKTITAT VTVVDKGKGA LEATVSYDDE KAFENTYTPA KTEVPVKKVW
KDENNQDGKR PTSVTVKLLA DGQDTGKTLE LNAANGWTGS FTNLDADKGG TPIQYTVVEV
TVAGYTSEIT GDAASGFTIT NSYSPETVDV KATKNWDDAN NQDGKRPTKI TINLLADGEK
VASKEVQAAA DGTWTATFEK LAKYKAGKEI KYTVTEEAVA EYEATITDFT ITNKYAPKEI
DYKVTKVWND ANNQDGKRPE SVTVQLYKKV GNADPVAVEG KKLTLTAKDK TDANTWVASF
TNLPQYEAGK EITYSIKEVD VPAGYEASVT GQVVTNTYNP ETVVLSGTKV WKDNNNQDGK
RTRSVKVQIL KNDKEVVQEI EVSEKTGWKF ESKKLPKYEN GKEIKYTVKE TAMTEYKATI
TTDKDGKYTI TNEHTPEKTA VKGHKIWKDE DNKDGIRPAS ITVKLLADGK ETGQTATVSE
TSGWTYEFTG LDRYREGKEI TYTVEEVNVP DGYTASVEGY NITNTHTPEK PTPGKPNEPG
KPKKGGELPN TGSESNQVAL AAGIALLGLG TGFLARRKKE D
//
