ID E6KX27_9PAST Unreviewed; 563 AA.
AC E6KX27;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00039545};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
DE AltName: Full=Long-chain acyl-CoA synthetase {ECO:0000256|ARBA:ARBA00042773};
GN Name=fadD2 {ECO:0000313|EMBL:EFU68058.1};
GN ORFNames=HMPREF9064_0721 {ECO:0000313|EMBL:EFU68058.1};
OS Aggregatibacter segnis ATCC 33393.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Aggregatibacter.
OX NCBI_TaxID=888057 {ECO:0000313|EMBL:EFU68058.1, ECO:0000313|Proteomes:UP000032871};
RN [1] {ECO:0000313|EMBL:EFU68058.1, ECO:0000313|Proteomes:UP000032871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33393 {ECO:0000313|EMBL:EFU68058.1,
RC ECO:0000313|Proteomes:UP000032871};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFU68058.1}.
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DR EMBL; AEPS01000003; EFU68058.1; -; Genomic_DNA.
DR RefSeq; WP_006717777.1; NZ_LS483443.1.
DR AlphaFoldDB; E6KX27; -.
DR STRING; 739.GCA_001059425_00375; -.
DR GeneID; 60800122; -.
DR HOGENOM; CLU_000022_59_9_6; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000032871; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd05936; FC-FACS_FadD_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF8; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EFU68058.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032871}.
FT DOMAIN 29..421
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 471..545
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 563 AA; 63222 MW; 5D47CEB3071B7C73 CRC64;
MTKPWFQNYP EGSERELDTS EYDSILDMFD KAIREHPDRA AYINMGQVLT FRKLEERSRA
FAAYLQNELK LERGERVALM MPNLLQYPIA LFGILRAGLV VVNVNPLYTP RELEHQLQDS
GAKAIVVVSN FASTLEKIVF NTSVKHVILT RMGDQLSFGK RTLVNFVVKY VKKLVPKYKL
PNAVTFREVL SVGKYRQYVR PQMERDDLAF LQYTGGTTGV AKGAMLSHGN IIVNVFQAKW
IAHPFVGDRS RERLAILALP LYHVFALTVN CLLFVELGVT AVLITNPRDI PGFVKELKKY
PFVAITGVNT LFNALLNNDE LKNVNFSALK LSVGGGMAIH QSVATRWHEL TGCNIIEGYG
MTECSPLIAA CPVNVVKHNG SIGVPVPNTD IRIVKEDGSE AALGEAGELW VKGEQVMKGY
WQRPEATAEV IKDGWMATGD IVIMDESYSL RIVDRKKDMI LVSGFNVYPN EIEDVAMLNN
KVAEVAAIGV PNDVSGETIK LFVVKKEDSL TRDELRQHCR KYLTGYKIPK DIEFREELPK
TNVGKILRRV LRDEEIAKRA TTA
//
