ID E6MED3_9FIRM Unreviewed; 425 AA.
AC E6MED3;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase {ECO:0000313|EMBL:EFV02458.1};
GN ORFNames=HMP0721_0366 {ECO:0000313|EMBL:EFV02458.1};
OS Pseudoramibacter alactolyticus ATCC 23263.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Pseudoramibacter.
OX NCBI_TaxID=887929 {ECO:0000313|EMBL:EFV02458.1, ECO:0000313|Proteomes:UP000004754};
RN [1] {ECO:0000313|EMBL:EFV02458.1, ECO:0000313|Proteomes:UP000004754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23263 {ECO:0000313|EMBL:EFV02458.1,
RC ECO:0000313|Proteomes:UP000004754};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV02458.1}.
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DR EMBL; AEQN01000007; EFV02458.1; -; Genomic_DNA.
DR RefSeq; WP_006597785.1; NZ_GL622359.1.
DR AlphaFoldDB; E6MED3; -.
DR STRING; 887929.HMP0721_0366; -.
DR eggNOG; COG2873; Bacteria.
DR HOGENOM; CLU_018986_4_2_9; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000004754; Unassembled WGS sequence.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF3; O-ACETYLHOMOSERINE SULFHYDRYLASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000004754};
KW Transferase {ECO:0000313|EMBL:EFV02458.1}.
FT MOD_RES 204
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 425 AA; 46164 MW; 1C6DEF2ABEF1391E CRC64;
MKKETQCIQA GYEPKNGESR LMPIVQSTTF KYDSSEAMGR LFDLEAEGYF YTRLQNPTSD
RVAAKIAALE GGTAAMLTAS GQAATFYSIF NLASADDHVV ASSAIYGGSF NLFNVTMRRM
GIDFTFVDPD CTDEALAAAF KPNTKAVFGE TIANPALIVF DIERFAKAAH AHGVPLIIDN
TFATPINCRP FEWGADIVTH STTKYMDGHD ATVGGCIVDS GQFDWMAHQE KFPGLTTPDE
SYHGITYAEK FGRGGAFITK ATAQLMRDLG ATPSPMNAYM LNLGLESLAV RMGRHCANAQ
QVAAFLEQHD QIAWVNYPGL PGNRYYERAR KYMPNGTCGV ISFGVKGGRK TAEAFMKHLK
IAMIATHVAD ARTCVLHPAS STHRQMTDEE LIAGGVAPDL VRLSVGIEAV DDIIVDLDQA
LRAVV
//
