ID E6MNP6_9BACT Unreviewed; 616 AA.
AC E6MNP6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:EFV04746.1};
GN Name=mrdA {ECO:0000313|EMBL:EFV04746.1};
GN ORFNames=HMPREF9420_1114 {ECO:0000313|EMBL:EFV04746.1};
OS Segatella salivae DSM 15606.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=888832 {ECO:0000313|EMBL:EFV04746.1, ECO:0000313|Proteomes:UP000003874};
RN [1] {ECO:0000313|EMBL:EFV04746.1, ECO:0000313|Proteomes:UP000003874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15606 {ECO:0000313|EMBL:EFV04746.1,
RC ECO:0000313|Proteomes:UP000003874};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV04746.1}.
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DR EMBL; AEQO01000111; EFV04746.1; -; Genomic_DNA.
DR RefSeq; WP_007134382.1; NZ_GL629647.1.
DR AlphaFoldDB; E6MNP6; -.
DR STRING; 888832.HMPREF9420_1114; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_10; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000003874; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003874};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..223
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 261..581
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 616 AA; 69420 MW; 769B58250551D995 CRC64;
MKDYTLENRR YVIGGVALAI VLVYIIRLFT IQLLSDDFKK NADSNAFLKK IDYPSRGAIY
DRNGKLMVYN QPSYDIMVVM NEAKDHIDTL ELCKALGISK EFFIKRMDDI KDRTKNPGYS
RFTEQLFMTQ LSDKEFSVFR EKMFRFPGFY VQKRSIRQYT YPYAAHVLGD IGEVSPANIE
EDDYYQPGDY IGKLGVEKYY EKELRGEKGV QIMLRDAHGR IQGSYRHGKF DRRPVAGRDL
TLSLDVKLQA LAERMLQGKI GSVVAIEPAT GEVLAMASSP TYDPRTLVGR QRSKVHVALS
KNVWKPLLNR SIMGQYPPGS TFKTTQALTY LTEGIITPNT MFTCHHGFSY RGLHVGCHGH
MSPLNLIEAI STSCNAYFCW GLYYMMGNRR KYHDVQEAMN RWRDYMVSMG FGYKLGIDLP
GEKRGLIPNA SFYDRAYHKS WNGLTVISIS IGQGEVNLTP LQIANLGATI ANRGYYYTPH
VVRKVQGLPL DTAFTHRHRT MASERAYSAV VAGMRSSALK GTCKALGHLP FTVCGKTGTA
QNRGQDHSVF MGFAPMNNPK IAIAVYVENG GFGADFAVPI AGVLFEQYLT GKLSPSAERM
AEALQNRRIA YGSHNR
//