ID E6NRV2_HELPQ Unreviewed; 440 AA.
AC E6NRV2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=N-acetylmuramoyl-L-alanine amidase {ECO:0000313|EMBL:BAJ59868.1};
GN Name=amiA {ECO:0000313|EMBL:BAJ59868.1};
GN OrderedLocusNames=HPF57_0794 {ECO:0000313|EMBL:BAJ59868.1};
OS Helicobacter pylori (strain F57).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=866346 {ECO:0000313|EMBL:BAJ59868.1, ECO:0000313|Proteomes:UP000008082};
RN [1] {ECO:0000313|EMBL:BAJ59868.1, ECO:0000313|Proteomes:UP000008082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F57 {ECO:0000313|EMBL:BAJ59868.1,
RC ECO:0000313|Proteomes:UP000008082};
RX PubMed=21575176; DOI=10.1186/1471-2180-11-104;
RA Kawai M., Furuta Y., Yahara K., Tsuru T., Oshima K., Handa N.,
RA Takahashi N., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.;
RT "Evolution in an oncogenic bacterial species with extreme genome
RT plasticity: Helicobacter pylori East Asian genomes.";
RL BMC Microbiol. 11:104-104(2011).
RN [2] {ECO:0000313|EMBL:BAJ59868.1, ECO:0000313|Proteomes:UP000008082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F57 {ECO:0000313|EMBL:BAJ59868.1,
RC ECO:0000313|Proteomes:UP000008082};
RX PubMed=21212362; DOI=10.1073/pnas.1012579108;
RA Furuta Y., Kawai M., Yahara K., Takahashi N., Handa N., Tsuru T.,
RA Oshima K., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.;
RT "Birth and death of genes linked to chromosomal inversion.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:1501-1506(2011).
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DR EMBL; AP011945; BAJ59868.1; -; Genomic_DNA.
DR RefSeq; WP_000961064.1; NC_017367.1.
DR AlphaFoldDB; E6NRV2; -.
DR KEGG; hex:HPF57_0794; -.
DR PATRIC; fig|866346.4.peg.850; -.
DR HOGENOM; CLU_014322_11_1_7; -.
DR Proteomes; UP000008082; Chromosome.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd02696; MurNAc-LAA; 1.
DR Gene3D; 3.40.630.40; Zn-dependent exopeptidases; 1.
DR InterPro; IPR002508; MurNAc-LAA_cat.
DR PANTHER; PTHR30404; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; 1.
DR PANTHER; PTHR30404:SF0; N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC; 1.
DR Pfam; PF01520; Amidase_3; 1.
DR SMART; SM00646; Ami_3; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
FT DOMAIN 278..433
FT /note="MurNAc-LAA"
FT /evidence="ECO:0000259|SMART:SM00646"
FT REGION 121..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..144
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 49975 MW; 7489B3C75FC0E967 CRC64;
MLVRLGVVAC LFWLHFAYAT TLKIINIVPF GSSSVKISFN QEIKKFKEVS LKNFKSYLEL
EAILTIPKKH YQFSKQSSIT IAQFSPKLAR VVISHAPKMT YEVKILKDKL YVSIVEKKPL
SRHQMAPKPP KHQTPKHHAL KHPTPKPAPK SIKKEAKEIK EKTLTKHARS KHTHSQWNER
NAKKEIPKKE AENESKNQVF IAEKNDTFIK TKRKKHKKIV LDAGHGGKDC GAMSANLVCE
KDIVLEVVKF LHKELKKRGY SVLLTRDKDI YIDLVARTEL ANKKSADLFI SVHANSIPKR
STSNAHGIET YFLSTARSER ARKVAEQENK DNVNLMDYFS KSLLLNSLNT QRLIVSNKLA
IDVQYGMLQS IRKNYPDVVD GGVREGPFWV LAGALMPSIL IEIGYNSHAI ESKRIQSKPY
QKILAKGIAD GIDSFFSKND
//
