ID   E6PR41_9ZZZZ            Unreviewed;       892 AA.
AC   E6PR41;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   13-SEP-2023, entry version 26.
DE   SubName: Full=Putative DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:CBH97396.1};
GN   ORFNames=CARN2_2868 {ECO:0000313|EMBL:CBH97396.1};
OS   mine drainage metagenome.
OC   unclassified sequences; metagenomes; ecological metagenomes.
OX   NCBI_TaxID=410659 {ECO:0000313|EMBL:CBH97396.1};
RN   [1] {ECO:0000313|EMBL:CBH97396.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Bertin P.N., Heinrich-Salmeron A., Pelletier E., Goulhen-Chollet F.,
RA   Arsene-Ploetze F., Gallien S., Calteau A., Vallenet D., Casiot C.,
RA   Chane-Woon-Ming B., Giloteaux L., Barakat M., Bonnefoy V., Bruneel O.,
RA   Chandler M., Cleiss J., Duran R., Elbaz-Poulichet F., Fonknechten N.,
RA   Lauga B., Mornico D., Ortet P., Schaeffer C., Siguier P.,
RA   Alexander Thil Smith A., Van Dorsselaer A., Weissenbach J., Medigue C.,
RA   Le Paslier D.;
RT   "Diversity of trophic interactions inside an arsenic-rich microbial
RT   ecosystem.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CBH97396.1}.
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DR   EMBL; CABM01000042; CBH97396.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6PR41; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        294..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        332..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        495..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        556..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          610..805
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   REGION          154..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          867..892
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  95123 MW;  51253E7D935E8AEC CRC64;
     MPILALGLLF GCWLQMQQPR LWPEDFYGAL AGAAILALSG LLAARLRNNG QPAQPAHIDP
     LGAVSGSRQG NVWRWFQTAL MFASAAALGY GTTGWRATGV LADRLAQPLW GQVVLVEGVV
     QSLPVRRANG TRFVFRPLHA AAGMPSRVMV SWHAPRQRPG PADAPVQTSP RNDQGAAQAP
     PVHPGEVWRL PLRLKPVHGA ANPAGFDAEL WLFEQGIGAT ATVSQARRFE PPKALGHLQD
     GADLALQSLR DRLRARIDAA LAGNPQAGTI AALALGDQAA IASREWTIYR ITGVAHLMSI
     SGLHITMLAW LAAWLAGFVW RRTAHLRHPG PLWLPTPTVA GVFGLLAATA YCLLAGFGVP
     AQRTLLMLAV GLSLRMSGLR ISWRQTLSWA LLAVLLWDPW ALMQAGFWLS FCAVGILFLA
     DPAKPRLEAA DPSESAMPAP AMAAPAPSRL RTLAHGAWSR LRAAGRSQWA VTLALAPLTL
     LFFQQIAILS PLANAAAIPV VTLWVAPLAV LGLLLPAPLD AWVWQAAAWV QAGLARVLAE
     LASWPQAQWH AAAPEWPALV LAALGVLALV LPWPWRLRAP GLALIIPLLL NPGQRPAEGH
     VEAWIADVGQ GMGIIVRTAR HTLLFDTGPT LGLQSDAGER VLLPLLHTLG ERRLDRVVLS
     HADSDHIGGA ASIARAYPGT AAVSSVAAER VLAMGYASAQ PCVAGMRWTW DGVDFQLLHP
     AAADPAPAQR TNAHSCVLRV ASRHGSLLLT GDIERAQERA LAAGPAADAL GVDLLLAAHH
     GSKTSSSAEF LQAVAPRLVA VQAGFMNSYG HPHADVLQRY ADLGLPVQRT DRAGALVWRD
     EHPAELESWR AKWPRYWQLP WPQASAPQRL SDTAQPAQAM AAGLGAGGQA TD
//