ID   E6PX17_9ZZZZ            Unreviewed;       487 AA.
AC   E6PX17;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Multidrug efflux system, subunit A {ECO:0000313|EMBL:CBH99476.1};
GN   Name=mdtA {ECO:0000313|EMBL:CBH99476.1};
GN   ORFNames=CARN3_0401 {ECO:0000313|EMBL:CBH99476.1};
OS   mine drainage metagenome.
OC   unclassified sequences; metagenomes; ecological metagenomes.
OX   NCBI_TaxID=410659 {ECO:0000313|EMBL:CBH99476.1};
RN   [1] {ECO:0000313|EMBL:CBH99476.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Bertin P.N., Heinrich-Salmeron A., Pelletier E., Goulhen-Chollet F.,
RA   Arsene-Ploetze F., Gallien S., Calteau A., Vallenet D., Casiot C.,
RA   Chane-Woon-Ming B., Giloteaux L., Barakat M., Bonnefoy V., Bruneel O.,
RA   Chandler M., Cleiss J., Duran R., Elbaz-Poulichet F., Fonknechten N.,
RA   Lauga B., Mornico D., Ortet P., Schaeffer C., Siguier P.,
RA   Alexander Thil Smith A., Van Dorsselaer A., Weissenbach J., Medigue C.,
RA   Le Paslier D.;
RT   "Diversity of trophic interactions inside an arsenic-rich microbial
RT   ecosystem.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CBH99476.1}.
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DR   EMBL; CABN01000018; CBH99476.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6PX17; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.420.20; -; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   NCBIfam; TIGR01730; RND_mfp; 1.
DR   PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR   PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          125..173
FT                   /note="Membrane fusion protein biotin-lipoyl like"
FT                   /evidence="ECO:0000259|Pfam:PF13533"
FT   REGION          431..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          165..192
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        431..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  52073 MW;  A678C69E9A78F64F CRC64;
     MASTAVSTLG TAVSAIIRMK KNEKLSLQEM ESVSVSQLTE TTSEELTPEP GKSGWVRAVV
     YIVLLALVAG GVWRVYKNRK LAAQQTASQA NALLNMPVPV QAAAVEQKPM PVYLTALGTV
     TPYYSVTVKA RVSGQLDHVS FTEGQLVKEG QTILVVDPRP YKAALDQAKG TLAHDEALLK
     DAQAEYARYK ALYEAGVVSK EQLDLELATQ GQYEGAIQSD KAAIETAQLQ LDWCTVQSPI
     SGKIGLRLVD PGNIITANTT NLVIINQIEP IAVYFTLPEN QLPQVLAMLR DQKNLVAEAF
     DRGDTTRLTT GQLLTADNQI DTTTGTDRLK AVFSNVDQQL FPNQFVNIHL IMEQRPKALV
     VPSAAIQTGN QGTFVWTVRH DQATNKDKVA MTPVKVALAE GQVTILDSGV SPGEQVVIDG
     ADRLHVGSVV EVSSSPTSQS DLPADASAGA STSMLAQKLN QSATSPHAHV GPAQGGGHEG
     GHSRTRP
//