ID E6R2X1_CRYGW Unreviewed; 663 AA.
AC E6R2X1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 08-NOV-2023, entry version 59.
DE SubName: Full=Cystathionine gamma-synthase, putative {ECO:0000313|EMBL:ADV21421.1};
GN OrderedLocusNames=CGB_C1710W {ECO:0000313|EMBL:ADV21421.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV21421.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV21421.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; CP000288; ADV21421.1; -; Genomic_DNA.
DR RefSeq; XP_003193208.1; XM_003193160.1.
DR AlphaFoldDB; E6R2X1; -.
DR GeneID; 10187086; -.
DR KEGG; cgi:CGB_C1710W; -.
DR VEuPathDB; FungiDB:CGB_C1710W; -.
DR eggNOG; KOG0053; Eukaryota.
DR HOGENOM; CLU_011302_1_0_1; -.
DR OrthoDB; 35837at2759; -.
DR Proteomes; UP000007805; Chromosome C.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR42699; -; 1.
DR PANTHER; PTHR42699:SF1; CYSTATHIONINE GAMMA-SYNTHASE-RELATED; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT REGION 175..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 72741 MW; 20A6305798B2864A CRC64;
MPTSAINLPA PIPLGCSVPV LTAHAISVSL PTWEDNVGYE EGDKRVVDRM ETGYPRFFIH
RSIQKLAALC LSKFGQPNEL CILLPTPRVA TAGRDFLAAQ DPPIRSRTVE FVICPSSKSL
TDPSSAKSLG IDCIELQILL FDKDKWPYGK AFWQHTGDGI TSRMAERALS FLGETPAGVQ
PRAPSPPTLE RPASKAPSSR NRHYSKRTGS VPPTPTTPSE SPYSTPQSST ILENPPVDSI
TDENLTSDLT TYLEERYGRN LPLFNAPLAK QALKRRIAGG LLPSDEDYGK IEDVARGAGS
GKKAVTEENV YLYPCGMSAI WHAHDISRIA RKLQGEAEGK SVCYGFPYTD TLKILNKWGP
GCHFLGTGGS DDINALEKIL VETEQNPNEP RILALFCEFP SNPLLRSPDL IRIRELADKY
GFFIVVDETI GNFINVEVVT YADIVVSSLT KIFSGDANVM GGSLILNPNG PHYDTLKAAQ
SSVYEDYYYP EDAVYMERNS RDYRARIKKV NDNAYAVCDF LHKRSLDDES TPAEGKVLKK
VYYPRYITPE TYSQAQRHPT LGKGGYGGLF SLTFTSLAAS RAFYDVIGCA KGPSLGTSFT
LASPYTILAH YLELDWAAGY GVEKGLVRIS VGQEDQSVLK TWFETALAAG EAAGRAENEA
QKA
//
